Evidence map›Paper›PMID 34213086›Full record

Trial reportCancer medicine2021

Yoga for cancer survivors with chemotherapy-induced peripheral neuropathy: Health-related quality of life outcomes.

W Iris Zhi, Raymond E Baser, Lillian M Zhi, Dristi Talukder, Qing S Li, Tina Paul, Clare Patterson, Lauren Piulson, Christina Seluzicki, Mary L Galantino and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03292328 (Yoga for Chemotherapy-Induced Peripheral Neuropathy in Breast and GYN Cancer Survivors), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03292328 nacompletednot on this map

Yoga for Chemotherapy-Induced Peripheral Neuropathy in Breast and GYN Cancer Survivors: A Pilot Study

TypeinterventionalSponsorMemorial Sloan Kettering Cancer CenterRan2017 to 2020Enrolled51ConditionsBreast Cancer, Peripheral Neuropathy, Gynecologic CancerArmsYoga, Wait List Control
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Yoga for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic.International journal of environmental research and public health · 2023
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

W Iris ZhiBreast Medicine Service, Solid Tumor Division, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4263-7272
Raymond E BaserDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lillian M ZhiWard Melville High School, East Setauket, NY, USA.
Dristi TalukderIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Qing S LiIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tina PaulIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Clare PattersonIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lauren PiulsonIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christina SeluzickiIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-8553-6810
Mary L GalantinoSchool of Health Sciences, Stockton University, Galloway, NJ, USA.
Ting BaoBreast Medicine Service, Solid Tumor Division, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4437-2597
Memorial Sloan Kettering Cancer Center · USUniversity of the Witwatersrand · ZA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Acupuncture for Chemothrapy-induced Peripheral Neuropathy Treatment (ACT)TrialR37CA248563 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Ting Bao · 2021 to 2026
$3.9M
Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) TrialR01CA251470 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BAO, TING · 2021 to 2025
$3.6M
Effect and Mechanism of Acupuncture for Cancer-related Cognitive Impairment (ENHANCE)R01CA240417 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MAO, JUN J · 2020 to 2024
$3.5M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA240417NCI NIH HHS R01 CA251470NCI NIH HHS R37 CA248563
6 · The paper itself

Abstract

backgroundYoga is a meditative movement therapy focused on mind-body awareness. The impact of yoga on health-related quality of life (HRQOL) outcomes in patients with chemotherapy-induced peripheral neuropathy (CIPN) is unclear.

methodsWe conducted a pilot randomized wait-list controlled trial of 8 weeks of yoga (n = 21) versus wait-list control (n = 20) for CIPN in 41 breast and gynecological cancer survivors with persistent moderate to severe CIPN. HRQOL endpoints were Hospital Anxiety and Depression Scale (HADS), Brief Fatigue Inventory (BFI), and Insomnia Severity Index (ISI). The Treatment Expectancy Scale (TES) was administered at baseline. We estimated mean changes and 95% confidence intervals (CIs) from baseline to weeks 8 and 12 and compared arms using constrained linear mixed models.

resultsAt week 8, HADS anxiety scores decreased -1.61 (-2.75, -0.46) in the yoga arm and -0.32 (-1.38, 0.75) points in the wait-list control arm (p = 0.099). At week 12, HADS anxiety scores decreased -1.42 (-2.57, -0.28) in yoga compared to an increase of 0.46 (-0.60, 1.53) in wait-list control (p = 0.017). There were no significant differences in HADS depression, BFI, or ISI scores between yoga and wait-list control. Baseline TES was significantly higher in yoga than in wait-list control (14.9 vs. 12.7, p = 0.019). TES was not associated with HADS anxiety reduction and HADS anxiety reduction was not associated with CIPN pain reduction.

conclusionsYoga may reduce anxiety in patients with CIPN. Future studies are needed to confirm these findings. CLINICAL TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Identifier: NCT03292328.

Indexed as

Quality of LifeAdultAgedAntineoplastic AgentsAnxietyCancer SurvivorsFatigueFemaleHumansMaleMiddle AgedNeoplasmsPeripheral Nervous System DiseasesSelf ReportTreatment OutcomeYogaAntineoplastic Agentsbreast cancerchemotherapyclinical cancer researchgynecological oncologyQOLquality of life

Identifiers

PMID34213086
PMCPMC8366077
OpenAlexW3176673920

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.