Evidence map›Paper›PMID 34213063›Full record

ArticleChemMedChem2021

N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability.

Francesca Ferlenghi, Michele Mari, Gabriella Gobbi, Gian Marco Elisi, Marco Mor, Silvia Rivara, Federica Vacondio, Silvia Bartolucci, Annalida Bedini, Fabiola Fanini and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesca FerlenghiDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Michele MariDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, 61029, Urbino, Italy.ORCID 0000-0002-3763-3587
Gabriella GobbiDepartment of Psychiatry, McGill University, Montreal, QC, H3A1A1, Canada.
Gian Marco ElisiDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Marco MorDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Silvia RivaraDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Federica VacondioDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Silvia BartolucciDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, 61029, Urbino, Italy.
Annalida BediniDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, 61029, Urbino, Italy.
Fabiola FaniniDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, 61029, Urbino, Italy.
Gilberto SpadoniDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, 61029, Urbino, Italy.

Funding

Italian Ministry for University and Research 20175SA5JJMinistry of Economy and Innovation of Quebec
6 · The paper itself

Abstract

The MT

Indexed as

AcetamidesAniline CompoundsAnimalsHumansLigandsMaleMicrosomes, LiverMolecular StructureRatsRats, Sprague-DawleyReceptor, Melatonin, MT1Receptor, Melatonin, MT2SolubilityThermodynamicsWaterAcetamidesAniline CompoundsLigandsN-(2-((3-methoxyphenyl)phenylamino)ethyl)acetamideReceptor, Melatonin, MT1Receptor, Melatonin, MT2Waterdrug-designlipophilicitymelatonin receptorsmetabolismpharmacokinetics

Identifiers

PMID34213063
PMCPMC8518537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.