ArticleChemphyschem : a European journal of chemical physics and physical chemistry2021
Simple Accurate Verification of Enthalpy-Entropy Compensation and Isoequilibrium Relationship.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Activation parameters, enthalpy-entropy compensation and the temperature-dependent activity of enzymes.Protein science : a publication of the Protein Society · 2026Article
- Distinct thermodynamic strategies in cello-oligosaccharide binding byApplied and environmental microbiology · 2026Article
- Activation parameters, enthalpy-entropy compensation and the temperature-dependent activity of enzymes.bioRxiv : the preprint server for biology · 2025Article
- Comment on "Structural Factors That Determine the Amylolytic Properties of Starch-Lipid Complexes".Journal of agricultural and food chemistry · 2025Article
- On Enthalpy-Entropy Compensation Characterizing Processes in Aqueous Solution.Entropy (Basel, Switzerland) · 2025Review
- Tuning TiFeACS applied energy materials · 2025Article
- Elucidating the Role of Groove Hydration on Stability and Functions of Biased DNA Duplexes in Cell-Like Chemical Environments.Journal of the American Chemical Society · 2024Article
- Extreme enthalpy‒entropy compensation in the dimerization of small solutes in aqueous solution.European biophysics journal : EBJ · 2024Review
- Comment on "Aggregation Interface and Rigid Spots Sustain the Stable Framework of a ThermophilicJournal of agricultural and food chemistry · 2023Article
- Comment on "The potential use of ultrasound-assisted bleaching in removing heavy metals and pigments from soybean oil using kinetic, thermodynamic and equilibrium modeling".Environmental science and pollution research international · 2022Article
- Simple Accurate Verification of Enthalpy-Entropy Compensation and Isoequilibrium Relationship.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Enthalpy-entropy compensation in the binding of peptide ligands to human Arc.Biochemistry and biophysics reports · 2021Article
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Abstract
In many experimental investigations of thermodynamic equilibrium or kinetic properties of series of similar reactions it is found that the enthalpies and entropies derived from Van 't Hoff or Arrhenius plots exhibit a strong linear correlation. The origin of this Enthalpy-Entropy compensation, which is strongly related to the coalescence tendency of Van 't Hoff or Arrhenius plots, is not necessarily due to a physical/chemical/biological process. It can also be a merely statistical artefact. A new method, called Combined K-CQF makes it possible both to quantify the degree of coalescence of experimental Van 't Hoff lines and to verify whether or not the Enthalpy-Entropy Compensation is of a statistical origin at a desired confidence level. The method is universal and can handle data sets with any degree of coalescence of Van 't Hoff (or Arrhenius) plots. The new method requires only a standard least square fit of the enthalpyΔH versus entropy ΔS plot to determine the two essential dimensionless parameters K and CQF. The parameter K indicates the position (in inverse temperature) of the coalescence region of Van 't Hoff plots and CQF is a quantitative measure of the smallest spread of the Van 't Hoff plots. The position of the (K, CQF) couple with respect to universal confidence contours determined from a large number of simulations of random Van 't Hoff plots indicates straightforwardly whether or not the ΔH-ΔS compensation is a statistical artefact.
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