Evidence map›Paper›PMID 34212858›Full record

ArticleeLife2021

An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction.

Steven R Sando, Nikhil Bhatla, Eugene Lq Lee, H Robert Horvitz

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. eLife · 2021
    Article
4 · The record

Corrections and comments

  • Commented on by
    2021
5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Steven R SandoHoward Hughes Medical Institute, Department of Biology, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-1101-9810
Nikhil BhatlaHoward Hughes Medical Institute, Department of Biology, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
Eugene Lq LeeHoward Hughes Medical Institute, Department of Biology, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0003-4725-4959
H Robert HorvitzHoward Hughes Medical Institute, Department of Biology, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-9964-9613
Howard Hughes Medical Institute · US

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Genetic Analysis of Nematode Egg Laying and Co-regulated Behavioral SystemsR01GM024663 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HORVITZ, H ROBERT · 1985 to 2025
$10.1M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
GENETIC ANALYSIS OF NEMATODE EGG-LAYINGR37GM024663 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HORVITZ, H R · 1991 to 2000
$363k
NIGMS NIH HHS R01 GM024663NIGMS NIH HHS R37 GM024663NIGMS NIH HHS T32 GM007287NIH HHS P40 OD010440
6 · The paper itself

Abstract

Neural control of muscle function is fundamental to animal behavior. Many muscles can generate multiple distinct behaviors. Nonetheless, individual muscle cells are generally regarded as the smallest units of motor control. We report that muscle cells can alter behavior by contracting subcellularly. We previously discovered that noxious tastes reverse the net flow of particles through the

Indexed as

AnimalsBiochemical PhenomenaCaenorhabditis elegansCalciumCalcium SignalingLightMotor NeuronsMuscle CellsMuscle ContractionNeural PathwaysPharynxCalciumbehaviorC. eleganshourglass circuit motifmotor controlneural circuitryneurosciencesubcellularly localized calcium transientssubcellular muscle contraction

Identifiers

PMID34212858
PMCPMC8331187
OpenAlexW3175374305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.