Evidence map›Paper›PMID 34212843›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2021

Retrospective cohort study investigating extent of pertussis transmission during a boarding school outbreak, England, December 2017 to June 2018.

Matt Edmunds, Rachel Mearkle, Jennifer Folliard, Charlotte Anderson, Sooria Balasegaram, Nastassya Chandra, Clare Sawyer, Norman K Fry, Sonia Ribeiro, Gemma Palmer and 8 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. JMM Profile:Journal of medical microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Matt EdmundsUK Field Epidemiology Training Programme, PHE National Infection Service, London, England.
Rachel MearkleThames Valley Health Protection Team, Public Health England, Chilton, England.
Jennifer FolliardThames Valley Health Protection Team, Public Health England, Chilton, England.
Charlotte AndersonField Service, PHE National Infection Service, London, England.
Sooria BalasegaramField Service, PHE National Infection Service, London, England.
Nastassya ChandraField Service, PHE National Infection Service, London, England.
Clare SawyerField Service, PHE National Infection Service, London, England.
Norman K FryImmunisation and Countermeasures Division, PHE National Infection Service, London, England.
Sonia RibeiroImmunisation and Countermeasures Division, PHE National Infection Service, London, England.
Gemma PalmerBoarding school health service, England.
Michael MorganBoarding school health service, England.
Gill UnderhillPHE Regional Microbiology Laboratory, Southampton General Hospital, Southampton, England.
Nusreen AhmadPHE Regional Microbiology Laboratory, Southampton General Hospital, Southampton, England.
Simon FriarPHE Regional Microbiology Laboratory, Southampton General Hospital, Southampton, England.
Andre CharlettStatistics, Modelling and Economics Department, PHE National Infection Service, London, England.
David LittRespiratory and Vaccine Preventable Bacteria Reference Unit, PHE National Infection Service, London, England.
Colin S BrownRespiratory and Vaccine Preventable Bacteria Reference Unit, PHE National Infection Service, London, England.
Gayatri AmirthalingamImmunisation and Countermeasures Division, PHE National Infection Service, London, England.
Southampton General Hospital · GBPublic Health England · GBHealthcare Infection Society · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

On 1 May 2018, a pertussis outbreak was declared and widespread vaccination recommended at an all-female secondary boarding school in southern England. We conducted a retrospective cohort study to determine the extent of pertussis transmission and identify risk factors in this semi-closed population. Of 504 students and staff assessed before post-exposure vaccination, 48% (n = 240) had evidence of pertussis. A sub-analysis of 409 students found that both residential dormitory (p = 0.05) and school year (p = 0.03) were associated with pertussis, with odds decreasing by 11% for each increase in school year (95% confidence interval: 0.7-20.2). Odds of pertussis were 1.7 times higher in those assumed to have received acellular vaccines for their primary course compared with those assumed to have received whole-cell vaccines (based on date of birth), although this difference was not significant (p = 0.12). Our findings support the need for timely, widespread vaccination following identification of cases among adolescents in a semi-closed United Kingdom (UK) setting and to review the evidence for the introduction of an adolescent pertussis booster to the UK routine vaccination programme.

Indexed as

Whooping CoughAdolescentDisease OutbreaksEnglandFemaleHumansImmunization, SecondaryPertussis VaccineRetrospective StudiesSchoolsVaccinationPertussis VaccineAdolescentBordetella pertussisinterventionschool

Identifiers

PMID34212843
PMCPMC8326658
OpenAlexW3173956405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.