Evidence map›Paper›PMID 34212544›Full record

ArticleAllergy, asthma & immunology research2021

Katleen Martens, Ilke De Boeck, Katarina Jokicevic, Filip Kiekens, Ricard Farré, Olivier M Vanderveken, Sven F Seys, Sarah Lebeer, Peter W Hellings, Brecht Steelant

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Allergy, asthma & immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Microbiology spectrum · 2025
    Trial
  2. Trial
  3. Review
  4. Journal of microbiology and biotechnology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. The nasal mutualistiScience · 2021
    Article
  10. Effect ofAllergy, asthma & immunology research · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Katleen MartensKU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium.ORCID https://orcid.org/0000-0002-8741-8252
Ilke De BoeckDepartment of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Antwerp, Belgium.ORCID https://orcid.org/0000-0003-0764-8515
Katarina JokicevicLaboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.ORCID https://orcid.org/0000-0003-1270-3689
Filip KiekensLaboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.ORCID https://orcid.org/0000-0002-6079-6595
Ricard FarréKU Leuven, Department of Chronic Diseases, Metabolism, and Aging (ChroMeTa), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-7158-171X
Olivier M VandervekenENT, Head and Neck Surgery and Communication Disorders, Antwerp University Hospital, Edegem, Belgium.ORCID https://orcid.org/0000-0002-4088-4213
Sven F SeysKU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium.ORCID https://orcid.org/0000-0002-4399-9892
Sarah LebeerDepartment of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Antwerp, Belgium. sarah.lebeer@uantwerpen.be.ORCID https://orcid.org/0000-0002-9400-6918
Peter W HellingsKU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium.ORCID https://orcid.org/0000-0001-6898-688X
Brecht SteelantKU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium. brecht.steelant@kuleuven.be.ORCID https://orcid.org/0000-0002-0358-9362
University of Antwerp · BEKU Leuven · BEGhent University Hospital · BE

Funding

Agentschap voor Innovatie door Wetenschap en Technologie 130260Belgian Federal Government IUAP P7/30European Research Council 26850Fonds Wetenschappelijk OnderzoekKU Leuven GOA 14/011KU Leuven PDMK/14/189
6 · The paper itself

Abstract

purposeA defective epithelial barrier has been demonstrated in chronic rhinosinusitis with nasal polyps (CRSwNP). Lactobacilli are shown to restore epithelial barrier defects in gastrointestinal disorders, but their effect on the airway epithelial barrier is unknown. In this study, hence, we evaluated whether the nasopharyngeal isolates

methods

resultsPatients with CRSwNP had a defective epithelial barrier which positively correlated with the relative abundance of lactobacilli-specific amplicons in the maxillary sinus.

conclusionsA defective epithelial barrier in CRSwNP may be associated with a decrease in relative abundance of lactobacilli-specific amplicons.

Indexed as

epitheliumLactobacillus caseilactobacillus sakeinasal polypspermeabiltysinusitistight junctionstoll like receptor 2

Identifiers

PMID34212544
PMCPMC8255346
OpenAlexW3134211019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.