Evidence map›Paper›PMID 34212527›Full record

ArticleCancer medicine2021

The predictive value of vessels encapsulating tumor clusters in treatment optimization for recurrent early-stage hepatocellular carcinoma.

Zhi-Yuan Chen, Zhi-Xing Guo, Liang-He Lu, Jie Mei, Wen-Ping Lin, Shao-Hua Li, Wei Wei, Rong-Ping Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  3. The prognostic value of vessels encapsulating tumor clusters (VETC) in patients with hepatocellular carcinoma: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhi-Yuan ChenDepartment of Gastroenterology, Hunan Provincial People' Hospital, Changsha, China.
Zhi-Xing GuoState Key Laboratory of Oncology in South China, Guangzhou, China.
Liang-He LuState Key Laboratory of Oncology in South China, Guangzhou, China.
Jie MeiState Key Laboratory of Oncology in South China, Guangzhou, China.
Wen-Ping LinState Key Laboratory of Oncology in South China, Guangzhou, China.
Shao-Hua LiState Key Laboratory of Oncology in South China, Guangzhou, China.
Wei WeiState Key Laboratory of Oncology in South China, Guangzhou, China.
Rong-Ping GuoState Key Laboratory of Oncology in South China, Guangzhou, China.ORCID 0000-0003-2799-3463
Sun Yat-sen University · CNHunan Provincial People's Hospital · CN

Funding

Hunan Provincial People's Hosptial RenShu Foundation RS201805National Natural Science Foundation of China 81871985Natural Science Foundation of Guangdong Province 2017A030310203
6 · The paper itself

Abstract

backgroundThe predictive value of vessels encapsulating tumor clusters (VETC) in recurrent early-stage hepatocellular carcinoma (HCC) remains unclear. Therefore, the aim of the present study was to investigate the prognostic significance of VETC in patients with recurrent early-stage HCC after repeat hepatic resection (RHR) or radiofrequency ablation (RFA).

methodsFrom December 2005 to December 2016, 138 patients receiving RHR and 188 patients receiving RFA were recruited. VETC was evaluated by immunohistochemical staining for CD34. The survival outcomes of patients with VETC pattern or not were investigated.

resultsThere was no significant difference between the RHR and RFA groups in disease-free survival (DFS) or overall survival (OS) as determined by the univariate analysis of the whole cohort. In the subgroup analysis of the VETC-positive cohort, the patients in the RHR group showed a longer median DFS time in contrast to those in the RFA group (15.0 vs. 5.0 months, p = 0.001). Similarly, the patients in the RHR group showed a longer median OS time in contrast to those in the RFA group (39.5 vs. 19 months, p = 0.001). In the VETC-negative cohort, no significant differences in DFS and OS rates between the RHR and RFA groups were observed (p > 0.05).

conclusionsThe results of our study suggested that RHR was relatively safe and superior to RFA in improving survival outcomes for recurrent early-stage HCC after initial hepatectomy. Furthermore, the VETC pattern may represent a reliable marker for selecting HCC patients who may benefit from RHR.

Indexed as

AdultCarcinoma, HepatocellularDisease-Free SurvivalFemaleFollow-Up StudiesHepatectomyHumansLiverLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiofrequency AblationRetrospective Studieshepatocellular carcinomaradiofrequency ablationrepeat hepatic resectionvessels encapsulating tumor cluster

Identifiers

PMID34212527
PMCPMC8366089
OpenAlexW3135484806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.