Evidence map›Paper›PMID 34212508›Full record

ArticleMolecular nutrition & food research2021

Antioxidant Effects of Elderberry Anthocyanins in Human Colon Carcinoma Cells: A Study on Structure-Activity Relationships.

Gudrun Pahlke, Katarina Ahlberg, Anne Oertel, Theresa Janson-Schaffer, Stephanie Grabher, Hans-Peter Mock, Andrea Matros, Doris Marko

Open access · hybridAbstract read
In one paragraph

Article in Molecular nutrition & food research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

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  7. In vivo antioxidant activity of rabbiteye blueberry (Journal of Zhejiang University. Science. B · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Gudrun PahlkeDepartment of Food Chemistry and Toxicology, University of Vienna, Waehringerstr. 38, Vienna, A-1090, Austria.ORCID 0000-0002-2755-6645
Katarina AhlbergDepartment of Food Chemistry and Toxicology, University of Vienna, Waehringerstr. 38, Vienna, A-1090, Austria.
Anne OertelDepartment of Physiology and Cell Biology, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK-Gatersleben), Corrensstr. 3, Gatersleben, D-06466, Germany.
Theresa Janson-SchafferDepartment of Food Chemistry and Toxicology, University of Vienna, Waehringerstr. 38, Vienna, A-1090, Austria.
Stephanie GrabherDepartment of Food Chemistry and Toxicology, University of Vienna, Waehringerstr. 38, Vienna, A-1090, Austria.
Hans-Peter MockDepartment of Physiology and Cell Biology, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK-Gatersleben), Corrensstr. 3, Gatersleben, D-06466, Germany.
Andrea MatrosDepartment of Physiology and Cell Biology, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK-Gatersleben), Corrensstr. 3, Gatersleben, D-06466, Germany.
Doris MarkoDepartment of Food Chemistry and Toxicology, University of Vienna, Waehringerstr. 38, Vienna, A-1090, Austria.ORCID 0000-0001-6568-2944
University of Vienna · ATLeibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeGlycosylation is a way to increase structure-stability of anthocyanins, yet compromises their bioactivity. The study investigates the antioxidant activity of purified cyanidin (Cy)-based anthocyanins and respective degradation products in Caco-2 clone C2BBe1 aiming to identify structure-activity relationships. RESULTS AND

methodsCyanidin 3-O-glucoside (Cy-3-glc) and cyanidin 3-O-sambubioside (Cy-3-sam) proved to be most potent regarding antioxidant properties and protection against hydrogen peroxide (H

conclusionMore complex residues and numbers of sugar moieties appear to be counterproductive for antioxidant activity. Other mechanisms than Nrf2-activation should be considered for protective effects.

Indexed as

Structure-Activity RelationshipAnthocyaninsAntioxidantsCaco-2 CellsCell SurvivalEnzymesFruit and Vegetable JuicesHumansOxidative StressSambucusAnthocyaninsAntioxidantsEnzymesanthocyanincyanidinelderberryoxidative stressphloroglucinol aldehyde

Identifiers

PMID34212508
PMCPMC8459241
OpenAlexW3173719667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.