Evidence map›Paper›PMID 34212499›Full record

SynthesisAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

A systematic review and meta-analysis of COVID-19 in kidney transplant recipients: Lessons to be learned.

Daan Kremer, Tobias T Pieters, Marianne C Verhaar, Stefan P Berger, Stephan J L Bakker, Arjan D van Zuilen, Jaap A Joles, Robin W M Vernooij, Bas W M van Balkom

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  19. COVID-19 and chronic kidney disease: a bibliometric analysis.Annals of medicine and surgery (2012) · 2024
    Review
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Daan KremerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-0011-115X
Tobias T PietersDepartment of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.
Marianne C VerhaarDepartment of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.
Stefan P BergerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Stephan J L BakkerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Arjan D van ZuilenDepartment of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.
Jaap A JolesDepartment of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.
Robin W M VernooijDepartment of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.
Bas W M van BalkomDepartment of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-3204-2059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplant recipients (KTR) may be at increased risk of adverse COVID-19 outcomes, due to prevalent comorbidities and immunosuppressed status. Given the global differences in COVID-19 policies and treatments, a robust assessment of all evidence is necessary to evaluate the clinical course of COVID-19 in KTR. Studies on mortality and acute kidney injury (AKI) in KTR in the World Health Organization COVID-19 database were systematically reviewed. We selected studies published between March 2020 and January 18th 2021, including at least five KTR with COVID-19. Random-effects meta-analyses were performed to calculate overall proportions, including 95% confidence intervals (95% CI). Subgroup analyses were performed on time of submission, geographical region, sex, age, time after transplantation, comorbidities, and treatments. We included 74 studies with 5559 KTR with COVID-19 (64.0% males, mean age 58.2 years, mean 73 months after transplantation) in total. The risk of mortality, 23% (95% CI: 21%-27%), and AKI, 50% (95% CI: 44%-56%), is high among KTR with COVID-19, regardless of sex, age and comorbidities, underlining the call to accelerate vaccination programs for KTR. Given the suboptimal reporting across the identified studies, we urge researchers to consistently report anthropometrics, kidney function at baseline and discharge, (changes in) immunosuppressive therapy, AKI, and renal outcome among KTR.

Indexed as

COVID-19Kidney TransplantationFemaleHumansMaleMiddle AgedSARS-CoV-2Transplant Recipientsclinical research/practicecomplication: infectiousimmunosuppressive regimensinfection and infectious agents - viralinfectious diseasekidney transplantation/nephrologymeta-analysistranslational research/science

Identifiers

PMID34212499
PMCPMC9292797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.