Evidence map›Paper›PMID 34212491›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2022

White paper on antimicrobial stewardship in solid organ transplant recipients.

Miranda So, Jonathan Hand, Graeme Forrest, Stephanie M Pouch, Helen Te, Monica I Ardura, Rachel M Bartash, Darshana M Dadhania, Jeffrey Edelman, Dilek Ince and 11 more

Open access · greenAbstract readConsensus Statement
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  15. Article
  16. The CDC antimicrobial use measure is not ready for public reporting or value-based programs.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023
    Article
  17. Antifungal stewardship in solid organ transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Review
  18. Safety and value of pretransplant antibiotic allergy delabeling in a quaternary transplant center.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  19. Perioperative antibiotic stewardship in the organ transplant setting.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Review
  20. Outpatient and peri-operative antibiotic stewardship in solid organ transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 20 institutions in 2 countries.

Miranda SoSinai Health System-University Health Network Antimicrobial Stewardship Program, University Health Network, Toronto, Canada.ORCID 0000-0002-2765-2063
Jonathan HandDepartment of Infectious Diseases, Ochsner Medical Center, The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, Louisiana, USA.ORCID 0000-0002-5752-9576
Graeme ForrestDepartment of Internal Medicine, Division of Infectious Diseases, Rush Medical College, Chicago, Illinois, USA.
Stephanie M PouchDivision of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-5628-2444
Helen TeCenter for Liver Diseases, The University of Chicago Medicine, Chicago, Illinois, USA.
Monica I ArduraDepartment of Pediatrics, Infectious Diseases and Host Defense, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA.
Rachel M BartashDivision of Infectious Diseases, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, New York, New York, USA.
Darshana M DadhaniaDepartment of Transplantation Medicine, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-7973-1521
Jeffrey EdelmanTransplant Services at UW Medical Center, Seattle, Washington, USA.
Dilek InceDepartment of Internal Medicine, Division of Infectious Diseases, University of Iowa Health Care, Carver College of Medicine, Iowa City, Iowa, USA.
Margaret R JorgensonUniversity of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA.ORCID 0000-0001-6088-9727
Sarah KabbaniOffice of Antibiotic Stewardship, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Erika D LeaseDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington, USA.
Deborah LevineDivision of Pulmonary and Critical Care Medicine and CT Surgery, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-2021-2233
Linda OhlerTransplant Institute New York University Langone Health, New York, New York, USA.
Gopi PatelIcahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jennifer PisanoAntimicrobial Stewardship and Infection Control, U Chicago Medicine, Chicago, Illinois, USA.
Michael L SpinnerDepartment of Pharmacy, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0001-5340-2802
Lilian AbboDepartment of Medicine, Miami Transplant Institute, Jackson Health System, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Elizabeth C VernaCenter for Liver Disease and Transplantation, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-9658-3751
Shahid HusainSinai Health System-University Health Network Antimicrobial Stewardship Program, University Health Network, Toronto, Canada.ORCID 0000-0002-9216-5229
University Health Network · CAAlbert Einstein College of Medicine · USCenters for Disease Control and Prevention · USCleveland Clinic · USColumbia University Irving Medical Center · USCornell University · USEmory University · USIcahn School of Medicine at Mount Sinai · USIndo-American Center · USMiami Transplant Institute · USNationwide Children's Hospital · USNYU Langone Health · USOchsner Medical Center · USRush University Medical Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of Chicago · USUniversity of Iowa Health Care · USUniversity of Washington · USUniversity of Washington Medical Center · USUW Health University Hospital · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Antimicrobial stewardship programs (ASPs) have made immense strides in optimizing antibiotic, antifungal, and antiviral use in clinical settings. However, although ASPs are required institutionally by regulatory agencies in the United States and Canada, they are not mandated for transplant centers or programs specifically. Despite the fact that solid organ transplant recipients in particular are at increased risk of infections from multidrug-resistant organisms, due to host and donor factors and immunosuppressive therapy, there currently are little rigorous data regarding stewardship practices in solid organ transplant populations, and thus, no transplant-specific requirements currently exist. Further complicating matters, transplant patients have a wide range of variability regarding their susceptibility to infection, as factors such as surgery of transplant, intensity of immunosuppression, and presence of drains or catheters in situ may modify the risk of infection. As such, it is not feasible to have a "one-size-fits-all" style of stewardship for this patient population. The objective of this white paper is to identify opportunities, risk factors, and ASP strategies that should be assessed with solid organ transplant recipients to optimize antimicrobial use, while producing an overall improvement in patient outcomes. We hope it may serve as a springboard for development of future guidance and identification of research opportunities.

Indexed as

Antimicrobial StewardshipOrgan TransplantationAnti-Bacterial AgentsHumansTissue DonorsTransplant RecipientsUnited StatesAnti-Bacterial Agentsantibiotic prophylaxisethics and public policyhealth services and outcomes researchinfection and infectious agentsorgan transplantation in general

Identifiers

PMID34212491
PMCPMC9695237
OpenAlexW3177423627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.