Evidence map›Paper›PMID 34212455›Full record

ArticleCancer science2021

Antitumor effect of WEE1 blockade as monotherapy or in combination with cisplatin in urothelial cancer.

Kaoru Murakami, Yuki Kita, Toru Sakatani, Akihiro Hamada, Kei Mizuno, Kenji Nakamura, Hideaki Takada, Keiyu Matsumoto, Takeshi Sano, Takayuki Goto and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Kaoru MurakamiDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0002-4226-3867
Yuki KitaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Toru SakataniDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Akihiro HamadaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kei MizunoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kenji NakamuraDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hideaki TakadaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Keiyu MatsumotoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takeshi SanoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takayuki GotoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shusuke AkamatsuDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ryoichi SaitoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tatsuaki TsuruyamaDepartment of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Osamu OgawaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takashi KobayashiDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0003-1069-2816
Kyoto University · JP

Funding

AstraZenecaMinistry of Education and Science 19H03790Ministry of Education and Science 25713055Ministry of Education and Science 26253078
6 · The paper itself

Abstract

Overcoming cisplatin (CDDP) resistance is a major issue in urothelial cancer (UC), in which CDDP-based chemotherapy is the first-line treatment. WEE1, a G

Indexed as

AgedAged, 80 and overAnimalsAntineoplastic AgentsApoptosisCell Cycle ProteinsCell Line, TumorCell ProliferationCisplatinDrug SynergismDrug Therapy, CombinationEnzyme InhibitorsFemaleGene Knockdown TechniquesHumansMaleadavosertibAntineoplastic AgentsCell Cycle ProteinsCisplatinEnzyme InhibitorsProtein-Tyrosine KinasesPyrazolesPyrimidinonesTP53 protein, humanTumor Suppressor Protein p53WEE1 protein, humancell cyclecisplatinp53urothelial cancerWEE1

Identifiers

PMID34212455
PMCPMC8409401
OpenAlexW3173841572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.