Evidence map›Paper›PMID 34212423›Full record

ArticleThe Journal of dermatology2021

Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes.

Shinichi Watanabe, Ken Iozumi, Masatoshi Abe, Yoshiko Ito, Takashi Uesugi, Takashi Onoduka, Ichiro Kato, Fumihiro Kato, Kazuo Kodama, Hidetoshi Takahashi and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Onychomycosis: Old and New.Journal of fungi (Basel, Switzerland) · 2023
    Review
  2. Dermatophytomas: Clinical Overview and Treatment.Journal of fungi (Basel, Switzerland) · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Shinichi WatanabeDepartment of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8216-9237
Ken IozumiDepartment of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
Masatoshi AbeSapporo Skin Clinic, Sapporo, Japan.ORCID https://orcid.org/0000-0002-8863-9428
Yoshiko ItoIto Skin Clinic, Sapporo, Japan.
Takashi UesugiUesugi Dermatology Clinic, Sapporo, Japan.
Takashi OnodukaAsanuma Dermatology Clinic, Chitose, Japan.
Ichiro KatoEniwa Station Dermatology Clinic, Eniwa, Japan.
Fumihiro KatoKato Dermatology Clinic, Sapporo, Japan.
Kazuo KodamaMegumino Dermatologic Clinic, Eniwa, Japan.
Hidetoshi TakahashiTakagi Dermatological Clinic, Obihiro, Japan.ORCID https://orcid.org/0000-0001-5375-3266
Osamu TakedaTakeda Dermatological Skin Care Clinic, Sapporo, Japan.
Koki TomizawaNopporo Dermatology Clinic, Ebetsu, Japan.
Yasuki TateishiShowa Skin Clinic, Hakodate, Japan.
Mizue FujiiDepartment of Dermatology, Asahikawa Medical University Hospital, Asahikawa, Japan.
Jun MayamaChitose Dermatology and Plastic Surgery Clinic, Chitose,, Japan.
Fumio MuramotoShinoro Dermatology Clinic, Sapporo, Japan.
Hidemi YasudaFukuzumi Dermatology Clinic, Sapporo, Japan.
Kiyomitsu YamanakaYamanaka Skincare Clinic, Sapporo, Japan.
Tsunao Oh-IAtago Dermatology Clinic, Tokyo, Japan.
Hiroko KasaiDepartment of Dermatology, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Ryoji TsuboiDepartment of Dermatology, Tokyo Medical University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1047-0351
Naoko HattoriNaoko Dermatology Clinic, Tokyo, Japan.
Ryuji MaruyamaMaruyama Dermatology Clinic, Tokyo, Japan.
Tokuya OmiQueen's Square Medical Center, Yokohama, Japan.
Harunari ShimoyamaDepartment of Dermatology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
Ichiro NakasuNemunoki Dermatology Clinic, Kawasaki, Japan.
Emiko Watanabe-OkadaDepartment of Dermatology, Saiseikai Yokohama-shi Tobu Hospital, Yokohama, Japan.
Shuhei NishimotoDepartment of Dermatology, Kawasaki Municipal Hospital, Kawasaki, Japan.
Takashi MochizukiDepartment of Dermatology, Kanazawa Medical University, Kanazawa, Japan.ORCID https://orcid.org/0000-0002-3793-980X
Masao FukuzawaDepartment of Dermatology, Ina Central Hospital, Ina, Japan.
Mariko SeishimaDepartment of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.ORCID https://orcid.org/0000-0003-0007-3632
Kazumitsu SugiuraDepartment of Dermatology, Fujita Health University, Toyoake, Japan.
Osamu YamamotoDivision of Dermatology, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine, Yonago, Japan.
Masahisa ShindoDepartment of Dermatology, National Hospital Organization Hamada Medical Center, Hamada, Japan.
Hiroe KiryuKiryu Dermatology Clinic, Fukuoka, Japan.
Masahiro KusuharaKusuhara Dermatology Clinic, Fukuoka, Japan.
Motoi TakenakaDepartment of Dermatology, Nagasaki University Hospital, Nagasaki, Japan.ORCID https://orcid.org/0000-0002-7045-2518

Funding

Kaken Pharmaceutical Co., Ltd.
6 · The paper itself

Abstract

Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.

Indexed as

OnychomycosisAdministration, TopicalAntifungal AgentsHumansTreatment OutcomeTriazolesAntifungal AgentsefinaconazoleTriazolesdermatophytomaefinaconazolelongitudinal spikeonychomycosistopical triazole antifungal

Identifiers

PMID34212423
PMCPMC8518491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.