ArticleJournal of neuroscience research2021
The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice.
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Article in Journal of neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- The Transcription Factors Six3 and Six6 in Neuromedin-S Neurons Differentially Affect Circadian Rhythms.Journal of neuroscience research · 2026Article
- Time-of-Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin-Deficient C57BL/6 Versus Melatonin Proficient CBA/B6 Hybrid Mice.Journal of pineal research · 2026Article
- The Chronological Trigger: The Orchestra Between Homeobox Genes and the Circadian Clock During Development.Biology of the cell · 2025Review
- Article
- Role of circadian clock in female embryo implantation.Frontiers in cell and developmental biology · 2025Review
- Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.bioRxiv : the preprint server for biology · 2024Article
- Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development.iScience · 2024Article
- The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice.Frontiers in endocrinology · 2023Article
- Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.Scientific reports · 2022Article
- Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice.Molecular and cellular endocrinology · 2022Article
- Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge.Endocrinology · 2022Review
- Placental circadian lincRNAs and spontaneous preterm birth.Frontiers in genetics · 2022Article
- Low CLOCK and CRY2 in 2nd trimester human maternal blood and risk of preterm birth: a nested case-control study†.Biology of reproduction · 2021Article
- Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1.Molecular and cellular endocrinology · 2021Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Hanne M HoffmannDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-1555-1369
Jason D MeadowsDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Joseph A BreuerDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Alexandra M YawDepartment of Animal Science and the Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI, USA.ORCID 0000-0003-4415-4450
Duong NguyenDepartment of Animal Science and the Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI, USA.
Karen J TonsfeldtDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8044-8857
Austin Y ChinDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Brooke M DevriesDepartment of Animal Science and the Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI, USA.
Crystal TrangDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Haley J OosterhouseDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Jessica Sora LeeDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
Jeffrey W DoserCANR Statistical Consulting Center, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-8950-9895
Michael R GormanCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-6122-8437
David K WelshCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-9121-3164
Pamela L MellonDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8856-0410
University of California San Diego · USMichigan State University · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MYeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MTestosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2014 to 2018
$8.6MThe Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAWSON, MARK ANDREW · 1985 to 2020
$7.5MTRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8MNEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUSR01DK044838 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1991 to 2011
$3.8MNeurosecretory Gene Expression in the HypothalamusR01HD100580 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 2020 to 2024
$2.7MReproductive and Developmental Sciences Training Program - T32T32HD087166 · NICHD · MICHIGAN STATE UNIVERSITY · PI Ronald L Chandler, Keith E Latham · 2016 to 2026
$2.5MCRR LIGAND ASSAY AND ANALYSIS CORER24HD102061 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2019 to 2023
$2.2MNeurosecretory Gene Expression in the HypothalamusR01HD072754 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 2012 to 2016
$1.7MBLRD VA I01 BX001146NCI NIH HHS P30 CA023100NICHD NIH HHS F32 HD090837NICHD NIH HHS K99 HD084759NICHD NIH HHS P50 HD012303NICHD NIH HHS P50 HD028934NICHD NIH HHS R00 HD084759NICHD NIH HHS R01 HD072754NICHD NIH HHS R01 HD082567NICHD NIH HHS R01 HD100580NICHD NIH HHS R24 HD102061NICHD NIH HHS T32 HD007203NICHD NIH HHS T32 HD087166NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK044838NIEHS NIH HHS P42 ES010337NINDS NIH HHS P30 NS047101
Abstract
The homeodomain transcription factors sine oculis homeobox 3 (Six3) and ventral anterior homeobox 1 (Vax1) are required for brain development. Their expression in specific brain areas is maintained in adulthood, where their functions are poorly understood. To identify the roles of Six3 and Vax1 in neurons, we conditionally deleted each gene using Synapsin
Indexed as
AnimalsCircadian RhythmEye ProteinsFemaleFertilityHomeobox Protein SIX3Homeodomain ProteinsMaleMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeuropeptidesNIH 3T3 CellsRunningSuprachiasmatic NucleusEye ProteinsHomeobox Protein SIX3Homeodomain ProteinsNerve Tissue ProteinsNeuropeptidesVax1 protein, mousecircadianconditional knock-outluteinizing hormone surgePER2::luciferasesix homeobox 3ventral anterior homeobox 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.