Evidence map›Paper›PMID 34212297›Full record

ArticleNeuroscience bulletin2022

A Neural Circuit Mechanism Controlling Breathing by Leptin in the Nucleus Tractus Solitarii.

Hongxiao Yu, Luo Shi, Jinting Chen, Shirui Jun, Yinchao Hao, Shuang Wang, Congrui Fu, Xiang Zhang, Haiyan Lu, Sheng Wang and 1 more

Open access · greenAbstract read
In one paragraph

Article in Neuroscience bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Leptin alleviates obesity hypoventilationbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hongxiao YuDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Luo ShiDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Jinting ChenCore Facilities and Centers, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Shirui JunDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Yinchao HaoDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Shuang WangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Congrui FuSchool of Nursing, Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Xiang ZhangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Haiyan LuDepartment of Orthodontics, College of Stomatology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Sheng WangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. wangsheng@hebmu.edu.cn.ORCID https://orcid.org/0000-0001-9579-4808
Fang YuanDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. yuanfphy@163.com.
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptin, an adipocyte-derived peptide hormone, has been shown to facilitate breathing. However, the central sites and circuit mechanisms underlying the respiratory effects of leptin remain incompletely understood. The present study aimed to address whether neurons expressing leptin receptor b (LepRb) in the nucleus tractus solitarii (NTS) contribute to respiratory control. Both chemogenetic and optogenetic stimulation of LepRb-expressing NTS (NTS

Indexed as

LeptinSolitary NucleusMembrane PotentialsNeuronsLeptinChemogeneticsLeptinNeural circuitNucleus tractus solitariiVentilation

Identifiers

PMID34212297
PMCPMC8821766
OpenAlexW3174664853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.