ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021
Monitoring cerebrovascular reactivity in pediatric traumatic brain injury: comparison of three methods.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebrovascular autoregulation and preterm brain injury: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Clinical Applications of Point-of-Care and Diagnostic Transcranial Doppler in the Pediatric Acute Care Setting: A Scoping Review.Neurocritical care · 2026Article
- Untangling discrepancies between cerebrovascular autoregulation correlation coefficients: An exploration of filters, coherence and power.Physiological reports · 2025Article
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia.Reviews in the neurosciences · 2024Review
- The State of the Field of Pediatric Multimodality Neuromonitoring.Neurocritical care · 2024Review
- Neuromonitoring in Children with Traumatic Brain Injury.Neurocritical care · 2024Review
- Intracranial Pressure and Its Related Parameters in the Management of Severe Pediatric Traumatic Brain Injury.Advances in neurobiology · 2024Review
- Early Cerebrovascular Autoregulation in Neonates with Congenital Heart Disease.Children (Basel, Switzerland) · 2022Article
- The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up.Intensive care medicine · 2022Review
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5 authors.
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Abstract
purposeTo study three different methods of monitoring cerebral autoregulation in children with severe traumatic brain injury.
methodsProspective cohort study of all children admitted to the pediatric intensive care unit at a university-affiliated hospital with severe TBI over a 4-year period to study three different methods of monitoring cerebral autoregulation: pressure-reactivity index (PRx), transcranial Doppler derived mean flow velocity index (Mx), and near-infrared spectroscopy derived cerebral oximetry index (COx).
resultsTwelve patients were included in the study, aged 5 months to 17 years old. An empirical regression analyzing dependence of PRx on cerebral perfusion pressure (CPP) displayed the classic U-shaped distribution, with low PRx values (< 0.3) reflecting intact auto-regulation, within the CPP range of 50-100 mmHg. The optimal CPP was 75-80 mmHg for PRx and COx. The correlation coefficients between the three indices were as follows: PRx vs Mx, r = 0.56; p < 0.0001; PRx vs COx, r = 0.16; p < 0.0001; and COx vs Mx, r = 0.15; p = 0.022. The mean PRx with a cutoff value of 0.3 predicted correctly long-term outcome (p = 0.015).
conclusionsPRx seems to be the most robust index to access cerebrovascular reactivity in children with TBI and has promising prognostic value. Optimal CPP calculation is feasible with PRx and COx.
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