Evidence map›Paper›PMID 34212234›Full record

Trial reportClinical oral investigations2022

Evaluation of diode laser versus topical corticosteroid in management of Behcet's disease-associated oral ulcers: a randomized clinical trial.

Clair Sobhy Nagieb, Tarek Abd-ElHamid Harhash, Hala Lotfy Fayed, Shereen Ali

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03771768 (Active Control,Randomized,Double- Blinded Clinical Trial of BD), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03771768 naunknown statusnot on this map

Active Control,Randomized,Double- Blinded Clinical Trial of BD

TypeinterventionalSponsorCairo UniversityRan2019 to 2019Enrolled38ConditionsAutoimmune, Behcet SyndromeArmsDiode laser 980nm&100 mWatt, Triamcinolone Acetonide
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Clair Sobhy NagiebDepartment of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, 11 El-Saraya Street, Manial, Cairo, 11553, Egypt.
Tarek Abd-ElHamid HarhashDepartment of Laser Application in Dentistry, National Institute for Laser Enhanced Sciences, Cairo University, Cairo, Egypt.
Hala Lotfy FayedDepartment of Rheumatology & Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt.
Shereen AliDepartment of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, 11 El-Saraya Street, Manial, Cairo, 11553, Egypt. cherriesah@hotmail.com.ORCID http://orcid.org/0000-0003-3794-2491
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe current trial was conducted to assess the effect of diode laser therapy compared to topical corticosteroid in management of oral ulcers of BD. MATERIALS AND

methodsFifty patients were divided randomly into two parallel groups. The first group received 980 nm diode laser; the second group received topical corticosteroid (0.1% triamcinolone acetonide). The outcome measures included oral ulcer activity index (composite index), pain (VAS), number of oral ulcers, healing time, and oral health-related quality of life (OHIP-14). The collected data were analyzed for any statistical significance.

resultsA statistically significant difference was detected between laser and corticosteroid groups favoring laser on comparing composite index and VAS scores on the first and third days and on comparing number of ulcers on the third and fifth days. A statistically significant difference was detected between laser and corticosteroid groups on comparing scores of the questions assessing discomfort with eating food, irritability with other people, taste worsening, unsatisfactory diet, and painful aching on the first and/or third days. No adverse effects were reported by participants of both groups.

conclusionsDiode laser is efficient safe treatment modality for management of BD-associated oral ulcers. Diode laser was more efficient than triamcinolone acetonide in controlling pain and reducing oral ulcer activity. CLINICAL RELEVANCE: Laser therapy is efficient safe modality that could spare BD patient from adding a new medication to their long list, being just one visit compared to other regular daily regimen medications.

trial registrationClinicalTrials.gov registration number: NCT03771768.

Indexed as

Behcet SyndromeOral UlcerStomatitis, AphthousAdrenal Cortex HormonesHumansLasers, SemiconductorQuality of LifeAdrenal Cortex HormonesAphthous ulcerBehcet’s diseaseCorticosteroidLaserOral ulcerPhotobiomodulation therapy

Identifiers

PMID34212234
OpenAlexW3176479798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.