Evidence map›Paper›PMID 34212033›Full record

ArticleBioMed research international2021

High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.

Yury Oliveira Chaves, Flávio Ribeiro Pereira, Rebeca de Souza Pinheiro, Diego Rafael Lima Batista, Antônio Alcirley da Silva Balieiro, Marcus Vinicius Guimarães de Lacerda, Paulo Afonso Nogueira, Monick Lindenmeyer Guimarães

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
  2. Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yury Oliveira ChavesLaboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia (DCDIA), Instituto Leônidas e Maria Deane (ILMD)-Fiocruz Amazônia, Manaus CEP 69.057-070, Brazil.ORCID https://orcid.org/0000-0002-3940-4227
Flávio Ribeiro PereiraFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Instituto de Pesquisa Clínica Carlos Borborema, Manaus, Amazonas CEP 69040-000, Brazil.ORCID https://orcid.org/0000-0002-5826-6528
Rebeca de Souza PinheiroLaboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia (DCDIA), Instituto Leônidas e Maria Deane (ILMD)-Fiocruz Amazônia, Manaus CEP 69.057-070, Brazil.ORCID https://orcid.org/0000-0002-6892-538X
Diego Rafael Lima BatistaLaboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia (DCDIA), Instituto Leônidas e Maria Deane (ILMD)-Fiocruz Amazônia, Manaus CEP 69.057-070, Brazil.ORCID https://orcid.org/0000-0003-0324-2876
Antônio Alcirley da Silva BalieiroLaboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia (DCDIA), Instituto Leônidas e Maria Deane (ILMD)-Fiocruz Amazônia, Manaus CEP 69.057-070, Brazil.ORCID https://orcid.org/0000-0003-0358-3371
Marcus Vinicius Guimarães de LacerdaLaboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia (DCDIA), Instituto Leônidas e Maria Deane (ILMD)-Fiocruz Amazônia, Manaus CEP 69.057-070, Brazil.ORCID https://orcid.org/0000-0003-3374-9985
Paulo Afonso NogueiraLaboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia (DCDIA), Instituto Leônidas e Maria Deane (ILMD)-Fiocruz Amazônia, Manaus CEP 69.057-070, Brazil.ORCID https://orcid.org/0000-0001-9677-7225
Monick Lindenmeyer GuimarãesLaboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ CEP 21040-900, Brazil.ORCID https://orcid.org/0000-0002-8442-3427
Instituto Nacional de Pesquisas da Amazônia · BRFundação de Medicina Tropical · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virologic failure may occur because of poor treatment adherence and/or viral drug resistance mutations (DRM). In Brazil, the northern region exhibits the worst epidemiological scenarios for the human immunodeficiency virus (HIV). Thus, this study is aimed at investigating the genetic diversity of HIV-1 and DRM in Manaus. The cross-sectional study included people living with HIV on combined antiretroviral therapy and who had experienced virological failure during 2018-2019. Sequencing of the protease/reverse transcriptase (PR/RT) and C2V3 of the viral envelope gp120 (

Indexed as

AdultAnti-HIV AgentsAnti-Retroviral AgentsBrazilCross-Sectional StudiesDrug Resistance, ViralFemaleHIV-1HIV InfectionsHumansMaleMiddle AgedMutationReverse Transcriptase InhibitorsAnti-HIV AgentsAnti-Retroviral AgentsReverse Transcriptase Inhibitors

Identifiers

PMID34212033
PMCPMC8208851
OpenAlexW3166965054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.