Evidence map›Paper›PMID 34211785›Full record

ArticleJournal of nutrition and metabolism2021

Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population.

Rocco Capuano, Federica Marchese, Raffaella Sica, Eduardo Capuano, Marzia Manilia, Anna Grazia Iannone, Alessandro D'Ambrosio, Alvino Bisecco, Gioacchino Tedeschi, Antonio Gallo and 1 more

Abstract read
In one paragraph

Article in Journal of nutrition and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Nutrition and growth of primary ciliary dyskinesia patients: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Review
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  10. Observational
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  12. Potential role of vitamin D levels in amyotrophic lateral sclerosis cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rocco CapuanoCardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.
Federica MarcheseCardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.
Raffaella SicaCardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.
Eduardo CapuanoCardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.
Marzia ManiliaCardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.
Anna Grazia IannoneCardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.
Alessandro D'AmbrosioDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, Italy.
Alvino BiseccoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, Italy.
Gioacchino TedeschiDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, Italy.
Antonio GalloDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, Italy.
Vincenzo CapuanoCardiology Unit "G. Fucito" Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, Italy.ORCID https://orcid.org/0000-0001-9421-981X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D (25(OH)D) deficiency is a prevalent condition worldwide. However, the highest prevalence rates of 25(OH)D deficiency have been attributed to regions with higher latitude. A close association between 25(OH)D and cardio-cerebrovascular (CCV) risk factors and major health problems has been identified.

aimTo establish the prevalence of 25(OH)D deficiency and to investigate the relationship between 25(OH)D levels and CCV risk factors (blood cholesterol, triglycerides, glucose concentrations, body mass index, and systolic and diastolic blood pressure) in a cohort representative of Southern Italy.

methodsThe prevalence of 25(OH)D levels was evaluated in 1200 subjects aged 25-74 years (600 males and 600 females), enrolled in the "VIP" (from Italian for

resultsOnly 13.3% of females and 11.1% of males showed adequate serum concentrations of 25(OH)D (≥30 ng/ml), while 59.3% of females and 55.1% of males showed 25(OH)D deficient levels (<20 ng/ml). We observed an independent association between 25(OH)D concentrations and metabolic syndrome score, LDL cholesterol, HDL cholesterol, and corrected QT (cQT).

conclusionsWe report a high prevalence of 25(OH)D deficiency across the largest Italian adult population studied so far and, in particular, the first across Southern Italy; furthermore, we provide data on the association between 25(OH)D deficiency and higher CCV risk factors.

Identifiers

PMID34211785
PMCPMC8205572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.