Evidence map›Paper›PMID 34211734›Full record

ArticleRegenerative biomaterials2021

A facile, versatile hydrogel bioink for 3D bioprinting benefits long-term subaqueous fidelity, cell viability and proliferation.

Hongqing Chen, Fei Fei, Xinda Li, Zhenguo Nie, Dezhi Zhou, Libiao Liu, Jing Zhang, Haitao Zhang, Zhou Fei, Tao Xu

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Bioprinting for craniofacial reconstruction: A review of advancements, clinical use, and challenges.Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · 2025
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  11. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongqing ChenDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0002-5122-6056
Fei FeiDepartment of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Xinda LiBiomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Zhenguo NieDepartment of Orthopedics, Fourth medical center of PLA general hospital, Beijing 100048, China.
Dezhi ZhouBiomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Libiao LiuBiomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Jing ZhangEast China Institute of Digital Medical Engineering, Shangrao 334000, China.
Haitao ZhangEast China Institute of Digital Medical Engineering, Shangrao 334000, China.
Zhou FeiDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Tao XuBiomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both of the long-term fidelity and cell viability of three-dimensional (3D)-bioprinted constructs are essential to precise soft tissue repair. However, the shrinking/swelling behavior of hydrogels brings about inadequate long-term fidelity of constructs, and bioinks containing excessive polymer are detrimental to cell viability. Here, we obtained a facile hydrogel by introducing 1% aldehyde hyaluronic acid (AHA) and 0.375%

Indexed as

bioinkbioprintingcell viabilitysubaqueous fidelity

Identifiers

PMID34211734
PMCPMC8240632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.