Evidence map›Paper›PMID 34211730›Full record

ArticleRegenerative biomaterials2021

Click chemistry-based pre-targeting cell delivery for cartilage regeneration.

Cynthia M Co, Samira Izuagbe, Jun Zhou, Ning Zhou, Xiankai Sun, Joseph Borrelli, Liping Tang

Open access · goldAbstract read
In one paragraph

Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Beyond labeling: differential AcRegenerative biomaterials · 2026
    Article
  2. Article
  3. Biomolecule-releasing bioadhesive for glenoid labrum repair through induced host progenitor cell responses.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  4. Review
  5. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cynthia M CoDepartment of Bioengineering, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, USA.
Samira IzuagbeDepartment of Bioengineering, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, USA.
Jun ZhouDepartment of Bioengineering, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, USA.
Ning ZhouDepartment of Radiology, University of Texas Southwestern Medical, Dallas, TX 75390, USA.
Xiankai SunDepartment of Radiology, University of Texas Southwestern Medical, Dallas, TX 75390, USA.
Joseph BorrelliDepartment of Bioengineering, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, USA.
Liping TangDepartment of Bioengineering, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, USA.
The University of Texas at Arlington · USThe University of Texas Southwestern Medical Center · US

Funding

Interdisciplinary Training in Nanotechnology for Cardiovascular and Lung Diseases in North TexasT32HL134613 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NGUYEN, KYTAI TRUONG · 2017 to 2021
$1.1M
NHLBI NIH HHS T32 HL134613
6 · The paper itself

Abstract

A fraction of the OA patient population is affected by post-traumatic osteoarthritis (PTOA) following acute joint injuries. Stopping or reversing the progression of PTOA following joint injury could improve long-term functional outcomes, reduced disability, and medical costs. To more effectively treat articular cartilage injury, we have developed a novel cell-based therapy that involves the pre-targeting of apoptotic chondrocytes and the delivery of healthy, metabolically active chondrocytes using click chemistry. Specifically, a pre-targeting agent was prepared via conjugating apoptotic binding peptide (ApoPep-1) and

Indexed as

cartilage regenerationcell therapychondrocyteclick chemistry

Identifiers

PMID34211730
PMCPMC8240595
OpenAlexW3157662814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.