ArticleInternational journal of preventive medicine2021
Selenium, Zinc, and Copper Status in Euthyroid Nodular Goiter: A Cross-Sectional Study.
Article in International journal of preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Nutritional Status of Iodine and Association with Iron, Selenium, and Zinc in Population Studies: A Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases.International journal of molecular sciences · 2023Pooled it
- Association of occupational lead exposure with erythrocytic parameters and nitric oxide-related metabolites: a case-control study.Turkish journal of medical sciences · 2026Article
- Copper/zinc ratio and erythrocyte superoxide dismutase in patients with thyroid nodules.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases-A Literature Review.Nutrients · 2025Review
- The association between metal element levels and thyroid nodules in oilfield workers: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Serum trace elements show association with thyroperoxidase autoantibodies in Thyroid Imaging Reporting and Data System (TI-RADS) 4 nodules.Scientific reports · 2024Article
- The Role of Nutrition on Thyroid Function.Nutrients · 2024Review
- Determination of Serum Zinc and Phosphorus Levels in Patients with Hypothyroidism.Biological trace element research · 2024Article
- Multi-element analysis of metals in human pathological and unchanged thyroid glands - pilot study.Thyroid research · 2024Article
- Serum Selenium Level in Thyroid Cancer: A Case-Control Study.Medical journal of the Islamic Republic of Iran · 2024Article
- Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions.Frontiers in cellular and infection microbiology · 2024Review
- Essential Trace Elements in Scalp Hair of Residents across the Caspian Oil and Gas Region of Kazakhstan.Toxics · 2022Article
- Selenium and protozoan parasitic infections: selenocompounds and selenoproteins potential.Parasitology research · 2022Review
- The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study.Frontiers in nutrition · 2022Article
- Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases.Frontiers in pharmacology · 2022Review
- Selenium: An Element of Life Essential for Thyroid Function.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is known that some elements are needed for normal thyroid gland functions. Iodine and selenium are the most well-known trace elements necessary for thyroid metabolism. Selenium is involved in the formation of thyroid hormones and the structure of the deiodinases associated with the development of the thyroid gland. While the role of zinc in thyroid metabolism is at the T3 receptor level, the role of copper is yet not clear.
objectiveTo compare the levels of serum trace elements such as selenium, zinc, and copper between the patients with euthyroid nodular goiter and healthy participants.
methodsThis cross-sectional study included 98 patients with euthyroid multinodular goiter and 83 healthy subjects without thyroid disease. The demographics, thyroid hormone levels, and thyroid ultrasonography of the participants were recorded. Venous blood samples were centrifuged and sera samples were stored at -80°C until analysis of selenium, zinc, and copper levels. The levels of trace elements were determined by inductively coupled plasma-mass spectrometry (ICP-MS).
resultsWhile serum, zinc, and selenium levels were significantly higher in the control group than the nodular goiter group, the copper levels were similar in the two groups. Trace elements were not correlated with thyroid hormone levels and thyroid volumes. Patients in the nodular goiter group were analyzed according to their solitary and multiple nodule status. The solitary and multiple nodular goiter groups were similar in terms of copper, zinc, and selenium levels.
conclusionsDeficiency of selenium and zinc may be associated with nodular goiter. Replacement of these trace elements may be useful for the prevention of nodular goiter, especially in deficient regions.
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