ArticleTherapeutic advances in neurological disorders2021
Carotid intraplaque neovascularisation as a predictive factor for future vascular events in patients with mild and moderate carotid stenosis: an observational prospective study.
Article in Therapeutic advances in neurological disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Beyond stenosis: Can artificial intelligence redefine stroke risk assessment in contrast-enhanced carotid ultrasound?European radiology · 2026Article
- Features of B-mode ultrasound and contrast-enhanced ultrasound of carotid plaque based on deep learning enhance the prediction of vulnerable plaques associated with acute ischemic stroke.European radiology · 2026Article
- Dual-modal ultrasound radiomics model enhances identification of symptomatic carotid plaque: a multicenter retrospective study.The international journal of cardiovascular imaging · 2026Article
- Morphological and biomechanical characteristics of carotid plaques with mild stenosis using ultrafast and high-definition ultrasonography.European radiology · 2026Article
- Improved stroke risk stratification in carotid atherosclerosis: integrating intraplaque neovascularization into Carotid Plaque-RADS.BMC medical imaging · 2025Article
- Carotid intraplaque neovascularization for predicting ischemic cerebrovascular events in patients with hypertension.Quantitative imaging in medicine and surgery · 2025Article
- Establishment and validation of a risk prediction model for acute ischemic stroke in a carotid artery plaque population.Quantitative imaging in medicine and surgery · 2025Article
- Prediction of ischemic stroke in elderly hypertensive patients using carotid plaque superb microvascular imaging characteristics: a lasso-logistic regression model.Journal of medical ultrasonics (2001) · 2025Article
- The role of intraplaque neovascularization in recent and future ischemic stroke in patients with mild carotid stenosis.Ultrasonography (Seoul, Korea) · 2025Article
- Construction of vulnerable plaque prediction model based on multimodal vascular ultrasound parameters and clinical risk factors.Scientific reports · 2024Article
- Research Advance of Chinese Medicine in Treating Atherosclerosis: Focus on Lipoprotein-Associated Phospholipase A2.Chinese journal of integrative medicine · 2024Review
- Added Clinical Value of Intraplaque Neovascularization Detection to Color Doppler Ultrasound for Assessing Ischemic Stroke Risk.Neuropsychiatric disease and treatment · 2024Article
- Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques.Frontiers in neurology · 2023Review
- Intraplaque neovascularisation is associated with ischaemic events after carotid artery stenting: an observational prospective study.Therapeutic advances in neurological disorders · 2023Article
- Effect of evolocumab on the progression of intraplaque neovascularization of the carotid based on contrast-enhanced ultrasonography (EPIC study): A prospective single-arm, open-label study.Frontiers in pharmacology · 2022 · on this mapArticle
- The Value of Contrast-Enhanced Ultrasound in the Evaluation of Carotid Web.Frontiers in neurology · 2022Article
- Carotid Intraplaque Neovascularization and Future Vascular Events in Patients With Asymptomatic Carotid Stenosis.Frontiers in pharmacology · 2022Article
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7 authors.
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Abstract
backgroundIntraplaque neovascularisation (IPN) increases the vulnerability of plaques, which makes them more likely to rupture and increases the risk of vascular events. However, it is unclear whether IPN can predict future vascular events (stroke recurrence and cardiovascular events). Previous studies on IPN have focused on patients with severe stenosis but overlooked patients with mild and moderate stenosis. This study aimed to investigate whether IPN assessed by contrast-enhanced ultrasonography (CEUS) in patients with mild and moderate degrees of stenosis is associated with future vascular events.
methodsOne hundred and twenty-one patients participated in this study. 76 patients who met the inclusion and exclusion criteria were included in the final dataset of the study. IPN was graded from 0 to 2 according to the extent of the microbubbles assessed using CEUS. The degree of carotid stenosis was graded as mild, moderate, or severe. We recorded future vascular events during the follow-up. Univariate and multivariate logistic regression analyses were used to evaluate risk factors for future vascular events.
resultsAfter a follow-up period of 30 ± 6 months, 30 patients (39.5%) experienced subsequent vascular events. Compared with the 'non-recurrent' group, the 'recurrent' group showed a higher proportion of grade 2 neovascularisation (
conclusionIPN by CEUS was an independent predictor of future vascular events in patients with recent ischemic stroke, and the high proportion of neovascularisation in patients with mild and moderate stenosis requires more attention.
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