Evidence map›Paper›PMID 34211570›Full record

ReviewEvidence-based complementary and alternative medicine : eCAM2021

Therapeutic Potential of Phytoconstituents in Management of Alzheimer's Disease.

Anurag Kumar Singh, Sachchida Nand Rai, Anand Maurya, Gaurav Mishra, Rajendra Awasthi, Anshul Shakya, Dinesh Kumar Chellappan, Kamal Dua, Emanuel Vamanu, Sushil Kumar Chaudhary and 1 more

Abstract readReview
In one paragraph

Review in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. Inhibition of VDAC1 Rescues AMediators of inflammation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anurag Kumar SinghCentre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.ORCID https://orcid.org/0000-0003-2125-810X
Sachchida Nand RaiCentre of Biotechnology, University of Allahabad, Prayagraj 211002, India.ORCID https://orcid.org/0000-0001-8418-9549
Anand MauryaDepartment of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.ORCID https://orcid.org/0000-0001-6591-4135
Gaurav MishraDepartment of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.ORCID https://orcid.org/0000-0002-8969-0014
Rajendra AwasthiAmity Institute of Pharmacy, Amity University Uttar Pradesh, Noida 201303, Uttar Pradesh, India.ORCID https://orcid.org/0000-0002-1286-1874
Anshul ShakyaDepartment of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Assam 786004, Dibrugarh, India.ORCID https://orcid.org/0000-0002-8232-4476
Dinesh Kumar ChellappanDepartment of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur 57000, Malaysia.ORCID https://orcid.org/0000-0001-5567-6663
Kamal DuaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, New South Wales, Australia.ORCID https://orcid.org/0000-0002-7507-1159
Emanuel VamanuFaculty of Biotechnology, University of Agronomic Science and Veterinary Medicine, 59 Marasti Blvd, 1 District, 011464, Bucharest, Romania.ORCID https://orcid.org/0000-0002-3376-2058
Sushil Kumar ChaudharyFaculty of Pharmacy, DIT University, Mussoorie-Diversion Road, Makkawala, Dehradun 248 009, Uttarakhand, India.ORCID https://orcid.org/0000-0002-7964-0021
M P SinghCentre of Biotechnology, University of Allahabad, Prayagraj 211002, India.ORCID https://orcid.org/0000-0002-6236-856X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since primitive times, herbs have been extensively used in conventional remedies for boosting cognitive impairment and age-associated memory loss. It is mentioned that medicinal plants have a variety of dynamic components, and they have become a prominent choice for synthetic medications for the care of cognitive and associated disorders. Herbal remedies have played a major role in the progression of medicine, and many advanced drugs have already been developed. Many studies have endorsed practicing herbal remedies with phytoconstituents, for healing Alzheimer's disease (AD). All the information in this article was collated from selected research papers from online scientific databases, such as PubMed, Web of Science, and Scopus. The aim of this article is to convey the potential of herbal remedies for the prospect management of Alzheimer's and related diseases. Herbal remedies may be useful in the discovery and advancement of drugs, thus extending new leads for neurodegenerative diseases such as AD. Nanocarriers play a significant role in delivering herbal medicaments to a specific target. Therefore, many drugs have been described for the management of age-linked complaints such as dementia, AD, and the like. Several phytochemicals are capable of managing AD, but their therapeutic claims are restricted due to their lower solubility and metabolism. These limitations of natural therapeutics can be overcome by using a targeted nanocarrier system. This article will provide the primitive remedies as well as the development of herbal remedies for AD management.

Identifiers

PMID34211570
PMCPMC8208882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.