ArticleFrontiers in genetics2021
Associations Between Sleep Quality and Health Span: A Prospective Cohort Study Based on 328,850 UK Biobank Participants.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Effect of aspirin on healthspan in community-dwelling older adults: the ASPirin in reducing events in the elderly study.Age and ageing · 2026Trial
- The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study.GeroScience · 2026Article
- Associations of sleep behaviors with white matter hyperintensity volume in middle-aged to older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of long-term PMBMC public health · 2026Article
- Self-reported sleep quality and frailty in middle-aged people living with HIV in an African setting: a pilot study.AIDS care · 2026Article
- Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sleep Disruption and Shift Work Associate with Increased Risk of Reproductive Endocrine Disorders: Evidence from UK Biobank and Mendelian Randomization.International journal of women's health · 2026Article
- The relationship between healthy sleep patterns and the risk of scoliosis: a large prospective cohort study.Frontiers in neuroscience · 2026Article
- Associations of sleep, lifestyle, and physiological markers with healthspan termination: a prospective cohort analysis.Sleep & breathing = Schlaf & Atmung · 2025Article
- PDSRS-LD: Personalized Deep Learning-Based Sleep Recommendation System Using Lifelog Data.Sensors (Basel, Switzerland) · 2025Article
- Bidirectional relationship between sleep problems and long COVID: a longitudinal analysis of data from the COVIDENCE UK study.BMJ open respiratory research · 2025Observational
- Inverted U-shaped relationship between sleep duration and phenotypic age in US adults: a population-based study.Scientific reports · 2024Article
- Apigenin: a natural molecule at the intersection of sleep and aging.Frontiers in nutrition · 2024Review
- Poor sleep quality and associated determinants among textile and garment manufacturing workers in Addis Ababa, Ethiopia.Sleep medicine: X · 2023Article
- Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants.Nature communications · 2023Article
- Multidimensional Sleep Health Prior to SARS-CoV-2 Infection and Risk of Post-COVID-19 Condition.JAMA network open · 2023Article
- Chronobiology of Parkinson's disease: Past, present and future.The European journal of neuroscience · 2023Review
- Article
- Association Between Snoring and Diabetes Among Pre- and Postmenopausal Women.International journal of general medicine · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo examine the associations between sleep quality and health span using a prospective cohort design based on the UK Biobank (UKB). MATERIALS AND
methodsThis longitudinal cohort study enrolled 328,850 participants aged between 37 and 73 years from UKB to examine the associations between sleep quality and risk of terminated health span. End of health span was defined by eight events strongly associated with longevity (cancer, death, congestive heart failure, myocardial infarction, chronic obstructive pulmonary disease, stroke, dementia, and diabetes), and a sleep score was generated according to five sleep behavioral factors (sleep duration, chronotype, sleeplessness, daytime sleepiness, and snoring) to characterize sleep quality. The hazard ratio (HR) and 95% confidence intervals (CIs) were calculated by multivariate-adjusted Cox proportional hazards model. Moreover, we calculated population attributable risk percentage (PAR%) to reflect the public health significance of healthy sleep quality.
resultsCompared with poor sleep quality, participants with healthy sleep quality had a 15% (HR: 0.85, 95% CI: 0.81-0.88) reduced risk of terminated health span, and those of less-healthy sleep quality had a 12% (HR: 0.88, 95% CI: 0.85-0.92) reduced risk. Linear trend results indicated that the risk of terminated health span decreased by 4% for every additional sleep score. Nearly 15% health span termination events in this cohort would have been prevented if a healthy sleep behavior pattern was adhered to (PAR%: 15.30, 95% CI: 12.58-17.93).
conclusionHealthy sleep quality was associated with a reduced risk of premature end of health span, suggesting healthy sleep behavior may extend health span. However, further studies are suggested for confirmation of causality and potential mechanism.
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