Evidence map›Paper›PMID 34211480›Full record

ArticleFrontiers in immunology2021

Mechanism of the Immunomodulatory Effect of the Combination of Live

Longxian Lv, Deguang Mu, Yiling Du, Ren Yan, Huiyong Jiang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. Journal of microbiology and biotechnology · 2026
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  6. A probiotic for preventing microplastic toxicity:Current research in food science · 2025
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  14. The regulatory effects ofFood science & nutrition · 2022
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  17. Effects of Fucoidan Isolated FromFrontiers in immunology · 2022
    Article
  18. Effect and Mechanism ofFrontiers in cellular and infection microbiology · 2022
    Article
  19. Probiotic Combination CBLEB AlleviatesJournal of inflammation research · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Longxian LvState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Deguang MuZhejiang Provincal People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
Yiling DuInstitute of Pharmaceutical Biotechnology and The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ren YanState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Huiyong JiangState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Zhejiang University · CNFirst Affiliated Hospital Zhejiang University · CNHangzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunodeficiency is a very common condition in suboptimal health status and during the development or treatment of many diseases. Recently, probiotics have become an important means for immune regulation. The present study aimed to investigate the mechanism of the immunomodulatory effect of a combination of live

Indexed as

Gastrointestinal MicrobiomeImmunocompromised HostProbioticsAnimalsBacillus cereusBifidobacterium longum subspecies infantisCyclophosphamideCytokinesDisease Models, AnimalDysbiosisEnergy MetabolismEnterococcus faecalisImmunologic Deficiency SyndromesLactobacillus acidophilusMaleMetabolomeCyclophosphamideCytokinesgut microbiotaimmunomodulationmetabolomeprobioticstranscriptome

Identifiers

PMID34211480
PMCPMC8239396
OpenAlexW3170741040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.