ArticleFrontiers in psychiatry2021
Case Report: Anti-flotillin 1/2 Autoantibody-Associated Atypical Dementia.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Repositioning synthetic glucocorticoids in psychiatric disease associated with neural autoantibodies: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Immunoreactivity to astrocytes in different forms of dementia: High prevalence of autoantibodies to GFAP.Brain, behavior, & immunity - health · 2023Article
- Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis.Brain communications · 2023Article
- Cerebrospinal Fluid Total Tau Protein Correlates With Longitudinal, Progressing Cognitive Dysfunction in Anti-Neural Autoantibody-Associated Dementia and Alzheimer's Dementia: A Case-Control Study.Frontiers in immunology · 2022Observational
- Current Nosology of Neural Autoantibody-Associated Dementia.Frontiers in aging neuroscience · 2021Review
- Case Report: Clinical and Imaging Characteristics of a Patient with Anti-flotillin Autoantibodies: Neuromyelitis Optica or Multiple Sclerosis?Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flotillin proteins are involved in neurodegeneration and T-cell immunity. Here, we report the case of 65-year-old woman who presented with dementia, depressive symptoms, and a patient history involving speech problems. As diagnostics methods we applied magnetic resonance imaging, clinical examination, extensive neuropsychological testing, and cerebrospinal fluid analysis. Neuropsychological testing revealed major cognitive decline in attentional, executive, and memory functions together with impaired activities of daily living. The cerebrospinal fluid showed elevated phosphorylated tau protein 181. We identified serum autoantibodies against the flotillin 1/2 complex. Immunotherapy entailing four cycles of high-dose steroids resulted in less cognitive dysfunction along with reduced depressive symptoms in the second follow-up after starting steroids. In conclusion: probable autoimmune-mediated dementia associated with anti-flotillin 1/2 complex autoantibodies expands the phenotypic spectrum of anti-flotillin 1/2 antibody disease.
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