Evidence map›Paper›PMID 34211388›Full record

ArticleFrontiers in aging neuroscience2021

Alix: A Candidate Serum Biomarker of Alzheimer's Disease.

Yingni Sun, Jin Hua, Gen Chen, Jianjie Li, Jiateng Yang, Hongwei Gao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues.Apoptosis : an international journal on programmed cell death · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yingni SunSchool of Life Sciences, Ludong University, Yantai, China.
Jin HuaDepartment of Anesthesiology, Kunhua Hospital, The First People's Hospital of Yunnan Province, Kunming, China.
Gen ChenDepartment of Hepatobiliary Surgery III, Guizhou Provincial People's Hospital, Guiyang, China.
Jianjie LiSchool of Life Sciences, Ludong University, Yantai, China.
Jiateng YangSchool of Life Sciences, Ludong University, Yantai, China.
Hongwei GaoSchool of Life Sciences, Ludong University, Yantai, China.
Ludong University · CNFirst People's Hospital of Yunnan Province · CNGuizhou Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common fatal neurodegenerative disease of the elderly worldwide. The identification of AD biomarkers will allow for earlier diagnosis and thus earlier intervention. The aim of this study was to find such biomarkers. It was observed that the expression of Alix was significantly decreased in brain tissues and serum samples from AD patients compared to the controls. A significant correlation between Alix levels and cognitive decline was observed (

Indexed as

diagnosisROC analysissensitivityspecificityvascular dementia

Identifiers

PMID34211388
PMCPMC8239346
OpenAlexW3172642086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.