Evidence map›Paper›PMID 34211371›Full record

ArticleFrontiers in cellular neuroscience2021

Developmental Changes in

Karen L Elliott, Jennifer Kersigo, Jeong Han Lee, Israt Jahan, Gabriela Pavlinkova, Bernd Fritzsch, Ebenezer N Yamoah

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. The transcription factorFrontiers in cellular neuroscience · 2024
    Article
  15. Article
  16. Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023
    Review
  18. Article
  19. Role of the Intermediate Filament Protein Peripherin in Health and Disease.International journal of molecular sciences · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Karen L ElliottDepartment of Biology, CLAS, The University of Iowa, Iowa City, IA, United States.
Jennifer KersigoDepartment of Biology, CLAS, The University of Iowa, Iowa City, IA, United States.
Jeong Han LeeDepartment of Physiology, School of Medicine, University of Nevada, Reno, Reno, NV, United States.
Israt JahanDepartment of Biology, CLAS, The University of Iowa, Iowa City, IA, United States.
Gabriela PavlinkovaInstitute of Biotechnology, Czech Academy of Sciences, Vestec, Czechia.
Bernd FritzschDepartment of Biology, CLAS, The University of Iowa, Iowa City, IA, United States.
Ebenezer N YamoahDepartment of Physiology, School of Medicine, University of Nevada, Reno, Reno, NV, United States.
University of Iowa · USUniversity of Nevada, Reno · USCzech Academy of Sciences, Institute of Biotechnology · CZ

Funding

Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2016 to 2025
$15.5M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
Calcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1M
Regulation of hair cell functionsR01DC015252 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2017 to 2021
$2.1M
NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC015252NIDCD NIH HHS R01 DC016099
6 · The paper itself

Abstract

The two types of spiral ganglion neurons (SGNs), types I and II, innervate inner hair cells and outer hair cells, respectively, within the mammalian cochlea and send another process back to cochlear nuclei in the hindbrain. Studying these two neuronal types has been made easier with the identification of unique molecular markers. One of these markers, peripherin, was shown using antibodies to be present in all SGNs initially but becomes specific to type II SGNs during maturation. We used mice with fluorescently labeled peripherin (

Indexed as

cochlear nucleusouter hair cellsperipherinPrph-eGFPtype II spiral ganglion neurons

Identifiers

PMID34211371
PMCPMC8239239
OpenAlexW3167317721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.