Evidence map›Paper›PMID 34211358›Full record

ArticleAdvanced functional materials2020

Innovations in 3-Dimensional Tissue Models of Human Brain Physiology and Diseases.

Michael L Lovett, Thomas J F Nieland, Yu-Ting L Dingle, David L Kaplan

Open access · greenAbstract read
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
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  7. Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michael L Lovett *Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155.
Thomas J F Nieland *Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155.
Yu-Ting L DingleDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155.
David L KaplanDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155.
Tufts University · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Functional three dimensional brain-like tissues to study mechanisms of traumatic brain injuryR01NS092847 · NINDS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2015 to 2019
$1.8M
Focal Sustained Release Chemotherapy-Loaded Biomaterials at Tumor SitesR01NS094218 · NINDS · TUFTS UNIVERSITY MEDFORD · PI CHIU, BILL, KAPLAN, DAVID L. · 2017 to 2021
$1.7M
NIBIB NIH HHS P41 EB002520NINDS NIH HHS R01 NS092847NINDS NIH HHS R01 NS094218
6 · The paper itself

Abstract

3-dimensional (3D) laboratory tissue cultures have emerged as an alternative to traditional 2-dimensional (2D) culture systems that do not recapitulate native cell behavior. The discrepancy between

Indexed as

bioengineeringneurodegenerative and psychiatric diseasesneurodevelopmentorganoidsstem cells

Identifiers

PMID34211358
PMCPMC8240470
OpenAlexW3010253539

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.