Evidence map›Paper›PMID 34211326›Full record

ArticleJournal of sports science & medicine2021

Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements.

Erik Duiven, Luc J C van Loon, Laila Spruijt, Willem Koert, Olivier M de Hon

Open access · bronzeAbstract read
In one paragraph

Article in Journal of sports science & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 63 citations in OpenAlex.

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  10. Nutrients · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Erik DuivenDoping Authority Netherlands, PO Box 5000, 2900 EA Capelle aan den IJssel, The Netherlands.
Luc J C van LoonDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
Laila SpruijtDoping Authority Netherlands, PO Box 5000, 2900 EA Capelle aan den IJssel, The Netherlands.
Willem KoertDoping Authority Netherlands, PO Box 5000, 2900 EA Capelle aan den IJssel, The Netherlands.
Olivier M de HonDoping Authority Netherlands, PO Box 5000, 2900 EA Capelle aan den IJssel, The Netherlands.
Netherlands Food and Consumer Product Safety Authority · NLMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sports nutrition supplements have previously been reported to contain undeclared doping substances. The use of such supplements can lead to general health risks and may give rise to unintentional doping violations in elite sports. To assess the prevalence of doping substances in a range of high-risk sports nutrition supplements available from Dutch web shops. A total of 66 sports nutrition supplements - identified as potentially high-risk products claiming to modulate hormone regulation, stimulate muscle mass gain, increase fat loss, and/or boost energy - were selected from 21 different brands and purchased from 17 web shops. All products were analyzed for doping substances by the UK life sciences testing company LGC, formerly known as the Laboratory of the Government Chemist, using an extended version of their ISO17025 accredited nutritional supplement screen. A total of 25 out of the 66 products (38%) contained undeclared doping substances, which included high levels of the stimulants oxilofrine, β-methylphenethylamine (BMPEA) and N,β-dimethylphenethylamine (NBDMPEA), the stimulant 4-methylhexan-2-amine (methylhexaneamine, 1,3-dimethylamylamine, DMAA), the anabolic steroids boldione (1,4-androstadiene-3,17-dione) and 5-androstene-3β,17α-diol (17α-AED), the beta-2 agonist higenamine and the beta-blocker bisoprolol. Based upon the recommended dose and the potential variability of analyte concentration, the ingestion of some products identified within this study could pose a significant risk of unintentional doping violations. In addition to inadvertent doping risks, the prescribed use of 3 products (4.5%) could likely impose general health risks.

Indexed as

Doping in SportsDrug ContaminationAdrenergic beta-AgonistsAdrenergic beta-AntagonistsAlkaloidsAmphetaminesAndrostadienesDietary SupplementsHumansPrevalenceRisk AssessmentTestosterone CongenersTetrahydroisoquinolines1,4-androstadiene-3,17-dioneAdrenergic beta-AgonistsAdrenergic beta-AntagonistsAlkaloidsAmphetaminesAndrostadieneshigenamineTestosterone CongenersTetrahydroisoquinolinesContaminationdietary supplementsdoping violationelite sporthealth risksprohibited substancesspiking

Identifiers

PMID34211326
PMCPMC8219275
OpenAlexW3138256206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.