ArticleNature communications2021
Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
- A practical guide to investigating biomolecular condensates: a comment from the plant community.Science China. Life sciences · 2026Review
- Xanthomonas Type III Effector XopN Targets Scaffold Protein OsRACK1B to Suppress Rice Immunity.Molecular plant pathology · 2026Article
- SUMO E3 ligase SIZ1 promotes nuclear condensate-mediated immune activation in Arabidopsis.Nature communications · 2026Article
- Liquid-liquid phase separation at the frontline of plant-pathogen battles.Plant communications · 2026Review
- Membrane curvature initiates Cdc42-FBP17-N-WASP clustering and actin nucleation.The EMBO journal · 2026Article
- The diverse roles of host membranes in plant-microbe interactions.PLoS pathogens · 2026Article
- Resistance gene againstFrontiers in plant science · 2026Review
- ricePSP: a database of rice phase separation-associated proteins.Genome biology · 2025Article
- The phase-separating Magnaporthe oryzae MoSpa2 complex organizes actin nucleation centers for plant infection.The Plant cell · 2025Article
- A catalogue of virulence strategies mediated by phytopathogenic effectors.Fundamental research · 2025Review
- Comparative metabolites analysis of resistant, susceptible and wild rice species in response to bacterial blight disease.BMC plant biology · 2025Article
- Membrane nanodomains to shape plant cellular functions and signaling.The New phytologist · 2025Review
- Molecular condensation of the CO/NF-YB/NF-YC/FT complex gates floral transition in Arabidopsis.The EMBO journal · 2025Article
- Chitosan stimulates root hair callose deposition, endomembrane dynamics, and inhibits root hair growth.Plant, cell & environment · 2025Article
- A Ralstonia solanacearum type III effector alters the actin and microtubule cytoskeleton to promote bacterial virulence in plants.PLoS pathogens · 2024Article
- The Type III Effector XopLInternational journal of molecular sciences · 2024Article
- Guidelines for naming and studying plasma membrane domains in plants.Nature plants · 2024Review
- Spa2 remodels ADP-actin via molecular condensation under glucose starvation.Nature communications · 2024Article
- Functional Analysis of Type III Effectors inPathogens (Basel, Switzerland) · 2024Article
- MolPhase, an advanced prediction algorithm for protein phase separation.The EMBO journal · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intrinsically disordered region (IDR) is a preserved signature of phytobacterial type III effectors (T3Es). The T3E IDR is thought to mediate unfolding during translocation into the host cell and to avoid host defense by sequence diversification. Here, we demonstrate a mechanism of host subversion via the T3E IDR. We report that the Xanthomonas campestris T3E XopR undergoes liquid-liquid phase separation (LLPS) via multivalent IDR-mediated interactions that hijack the Arabidopsis actin cytoskeleton. XopR is gradually translocated into host cells during infection and forms a macromolecular complex with actin-binding proteins at the cell cortex. By tuning the physical-chemical properties of XopR-complex coacervates, XopR progressively manipulates multiple steps of actin assembly, including formin-mediated nucleation, crosslinking of F-actin, and actin depolymerization, which occurs through competition for actin-depolymerizing factor and depends on constituent stoichiometry. Our findings unravel a sophisticated strategy in which bacterial T3E subverts the host actin cytoskeleton via protein complex coacervation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.