ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Spatial Representations in Rat Orbitofrontal Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 66 citations in OpenAlex.
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- Distributed neural codes of the 3D position in the marmoset frontal cortex and hippocampus.Nature communications · 2026Article
- Brain structural morphometry in non-musicians with superior pitch identification ability.Scientific reports · 2026Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Distinct orbitofrontal circuits with dorsal and ventral CA1 differentially regulate spatial memory and emotional behaviors.Frontiers in behavioral neuroscience · 2026Article
- The Quantum Brain: The Untold Story of Docosahexaenoic Acid's Role in Brain Evolution, Biophysics, and Cognition.International journal of molecular sciences · 2025Review
- Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal output suppresses orbitofrontal cortex schema cell formation.Nature neuroscience · 2025Article
- [Synchronized neural rhythms in rat hippocampal CA1 region and orbitofrontal cortex are involved in learning and memory consolidation in spatial goal-directed tasks].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Neural circuits for goal-directed navigation across species.Trends in neurosciences · 2024Review
- Cracking and Packing Information about the Features of Expected Rewards in the Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils.Current biology : CB · 2024Article
- Hippocampal and orbitofrontal neurons contribute to complementary aspects of associative structure.Nature communications · 2024Article
- Border cells without theta rhythmicity in the medial prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Distance and grid-like codes support the navigation of abstract social space in the human brain.eLife · 2024Article
- A persistent prefrontal reference frame across time and task rules.Nature communications · 2024Article
- Widespread coding of navigational variables in prefrontal cortex.Current biology : CB · 2023Article
- Generalization of cognitive maps across space and time.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex.Nature communications · 2023Article
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4 authors at 2 institutions in 1 country.
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Abstract
The orbitofrontal cortex (OFC) and hippocampus share striking cognitive and functional similarities. As a result, both structures have been proposed to encode "cognitive maps" that provide useful scaffolds for planning complex behaviors. However, while this function has been exemplified by spatial coding in neurons of hippocampal regions-particularly place and grid cells-spatial representations in the OFC have been investigated far less. Here we sought to address this by recording OFC neurons from male rats engaged in an open-field foraging task like that originally developed to characterize place fields in rodent hippocampal neurons. Single-unit activity was recorded as rats searched for food pellets scattered randomly throughout a large enclosure. In some sessions, particular flavors of food occurred more frequently in particular parts of the enclosure; in others, only a single flavor was used. OFC neurons showed spatially localized firing fields in both conditions, and representations changed between flavored and unflavored foraging periods in a manner reminiscent of remapping in the hippocampus. Compared with hippocampal recordings taken under similar behavioral conditions, OFC spatial representations were less temporally reliable, and there was no significant evidence of grid tuning in OFC neurons. These data confirm that OFC neurons show spatial firing fields in a large, two-dimensional environment in a manner similar to hippocampus. Consistent with the focus of the OFC on biological meaning and goals, spatial coding was weaker than in hippocampus and influenced by outcome identity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.