Evidence map›Paper›PMID 34210530›Full record

ArticleSurgery2022

Ambient particulate matter air pollution is associated with increased risk of papillary thyroid cancer.

Shkala Karzai, Zhenyu Zhang, Whitney Sutton, Jason Prescott, Dorry L Segev, Mara McAdams-DeMarco, Shyam S Biswal, Murugappan Ramanathan, Aarti Mathur

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026
    Pooled it
  2. Association Between Environmental Air Pollution and Thyroid Cancer and Nodules: A Systematic Review.Thyroid : official journal of the American Thyroid Association · 2024
    Pooled it
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  18. Urban Air Pollution Associated with the Incidence of Autoimmune Thyroid Diseases.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shkala KarzaiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Zhenyu ZhangDepartment of Global Health, Peking University School of Public Health, Beijing, China; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Whitney SuttonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: https://twitter.com/@WhitneySuttonMD.
Jason PrescottDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: https://twitter.com/@Dorry_Segev.
Mara McAdams-DeMarcoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address: https://twitter.com/@McAdamsDeMarco.
Shyam S BiswalDepartment of Environmental Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore MD.
Murugappan RamanathanDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: https://twitter.com/@MurrayRamanatha.
Aarti MathurDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: amathu10@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Clinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0M
Kidney transplantation in older, frail and cognitively impaired adults with ESRD: Balancing utility vs. justiceR01AG055781 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2017 to 2021
$4.2M
Hemodialysis-based interventions to preserve cognitive functionR01DK114074 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2018 to 2022
$3.9M
Investigating Effect of Air pollution and Host Defenses in SARS-CoV2 infectionU01ES026721 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI BISWAL, SHYAM, RAJAGOPALAN, SANJAY · 2016 to 2020
$3.8M
Developing personalized immunosuppression for older kidney transplant recipientsR01DK120518 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2019 to 2022
$2.7M
Reducing geographic disparities in kidney and liver allocationR01DK111233 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WARREN, DANIEL S · 2016 to 2019
$2.5M
The Role of Nrf2 in Stabilizing the Epithelial Barrier in Particulate Matter Induced RhinosinusitisR01AI143731 · NIAID · JOHNS HOPKINS UNIVERSITY · PI RAMANATHAN, MURUGAPPAN · 2019 to 2023
$2.2M
Crosstalk of LKB1 and KEAP1 mutations in driving growth of lung adenocarcinomaR01CA206155 · NCI · JOHNS HOPKINS UNIVERSITY · PI BISWAL, SHYAM · 2016 to 2020
$2.0M
Association of Fraility with Post thyroidectomy alterations in Voice, Swallowing, and Quality of LifeK23AG053429 · NIA · JOHNS HOPKINS UNIVERSITY · PI MATHUR, AARTI · 2017 to 2022
$1.0M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
NCI NIH HHS R01 CA206155NCI NIH HHS T32 CA126607NIAID NIH HHS K24 AI144954NIAID NIH HHS R01 AI143731NIA NIH HHS K23 AG053429NIA NIH HHS R01 AG055781NIDDK NIH HHS R01 DK111233NIDDK NIH HHS R01 DK114074NIDDK NIH HHS R01 DK120518NIEHS NIH HHS U01 ES026721
6 · The paper itself

Abstract

backgroundThe association between exposure to air pollution and papillary thyroid carcinoma is unknown. We sought to estimate the relationship between long-term exposure to the fine (diameter ≤ 2.5 μm) particulate matter component of air pollution and the risk of papillary thyroid cancer.

methodsAdult (age ≥18) patients with newly diagnosed papillary thyroid carcinoma between January 1, 2013 and December 31, 2016 across a single health system were identified using electronic medical records. Data from 1,990 patients with papillary thyroid carcinoma were compared with 3,980 age- and sex-matched control subjects without any evidence of thyroid disease. Cumulative fine (diameter <2.5 μm) particulate matter exposure was estimated by incorporating patients' residential zip codes into a deep learning neural networks model, which uses both meteorological and satellite-based measurements. Conditional logistic regression was performed to assess for association between papillary thyroid carcinoma and increasing fine (diameter ≤2.5 μm) particulate matter concentrations over 1, 2, and 3 years of cumulative exposure preceding papillary thyroid carcinoma diagnosis.

resultsIncreased odds of developing papillary thyroid carcinoma was associated with a 5 μg/m

conclusionIncreasing concentration of fine (diameter ≤2.5 μm) particulate matter in air pollution is significantly associated with the incidence of papillary thyroid carcinoma with 2 and 3 years of exposure. Our novel findings provide additional insight into the potential associations between risk factors and papillary thyroid carcinoma and warrant further investigation, specifically in areas with high levels of air pollution both nationally and internationally.

Indexed as

AdultAgedAir PollutantsAir PollutionCase-Control StudiesElectronic Health RecordsEnvironmental MonitoringFemaleHumansIncidenceMaleMiddle AgedParticulate MatterRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsAir PollutantsParticulate Matter

Identifiers

PMID34210530
PMCPMC8688174
OpenAlexW3173953945

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.