Evidence map›Paper›PMID 34210501›Full record

ArticleThe American journal of cardiology2021

Lipoprotein(a) Testing Patterns in a Large Health System.

Michelle Kelsey, Courtney Page, Brooke Alhanti, Shannon L Rhodes, Shia T Kent, Eric Peterson, Neha Pagidipati

Open access · greenAbstract read
In one paragraph

Article in The American journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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  10. JACC. Advances · 2024
    Article
  11. Article
  12. Lipoprotein(a): An important piece of the ASCVD risk factor puzzle across diverse populations.American heart journal plus : cardiology research and practice · 2024
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Michelle KelseyDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address: michelle.kelsey@duke.edu.
Courtney PageDuke Clinical Research Institute, Durham, NC.
Brooke AlhantiDuke Clinical Research Institute, Durham, NC.
Shannon L RhodesCenter for Observational Research, Amgen Inc., Thousand Oaks, CA.
Shia T KentCenter for Observational Research, Amgen Inc., Thousand Oaks, CA.
Eric PetersonDivision of Cardiology, Department of Medicine, University of Texas Southwestern, Dallas, TX.
Neha PagidipatiDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, NC; Duke Clinical Research Institute, Durham, NC.
Clinical Research Institute · USAmgen (United States) · USThe University of Texas Southwestern Medical Center · US

Funding

Postdoctoral Training in Cardiovascular Clinical ResearchT32HL069749 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2003 to 2023
$6.7M
NHLBI NIH HHS T32 HL069749
6 · The paper itself

Abstract

Lipoprotein (a) [Lp(a)] is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). As directed therapy for Lp(a) emerges, it is important to understand patterns of Lp(a) testing in routine clinical practice. We set out to characterize Lp(a) testing across a large academic health system. Using electronic health record (EHR) data from 2014 to 2019, we compared patients who underwent Lp(a) testing to date-matched peers who had low density lipoprotein (LDL-C) assessment alone. We analyzed ordering provider characteristics and rates of initiation of new lipid lowering therapy (LLT) within 12 months after testing. Of 1,296 adults with Lp(a) test results, 629 (48.5%) had prior history of ASCVD and 667 (51.4%) did not. Compared with those with LDL-C testing alone, individuals who underwent Lp(a) testing were more like to have a myocardial infarction or ischemic stroke at a young age and multiple prior cardiovascular events. Though the majority of Lp(a) tests were ordered in outpatient encounters, a higher proportion of Lp(a) tests compared with LDL-C tests were performed in the inpatient setting. Neurology and psychiatry were the most common specialty to order Lp(a) tests in our cohort. There was a significantly increased initiation of LLT after Lp(a) testing compared with LDL-C testing across all medication types. Consistent with guidelines, Lp(a) testing is used in those with early onset ASCVD, and among those with multiple cardiovascular events. Lp(a) testing is associated with more aggressive LLT in following year. Further research is needed to characterize Lp(a) testing across larger populations.

Indexed as

Academic Medical CentersAgedAmbulatory CareAtherosclerosisBlood Chemical AnalysisCardiovascular DiseasesCholesterol, LDLFemaleHeart Disease Risk FactorsHospitalizationHumansHyperlipidemiasHypolipidemic AgentsIschemic StrokeLipoprotein(a)MaleCholesterol, LDLHypolipidemic AgentsLipoprotein(a)

Identifiers

PMID34210501
PMCPMC9970036
OpenAlexW3176359589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.