Evidence map›Paper›PMID 34210383›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2021

Reference Intervals for Total T4 and Free T4 in Cynomolgus Macaques (

Joseph D Sciurba, Jennifer M Hayes, Seyed Mehdi Nouraie, Heather M Wilson, Jeffrey D Fortman, Lisa C Halliday

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Joseph D SciurbaBiologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois;, Email: jsciur2@uic.edu.
Jennifer M HayesPathology Services Unit, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin.
Seyed Mehdi NouraieDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Heather M WilsonUnit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan.
Jeffrey D FortmanBiologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois.
Lisa C HallidayBiologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois.
University of Illinois Chicago · USUniversity of Michigan–Ann Arbor · USUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
EXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9M
NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NIH HHS P51 OD011106
6 · The paper itself

Abstract

Thyroid diseases, associated with either increased or decreased concentrations of circulating thyroid hormones, are prevalent in both human and veterinary populations. Hypothyroidism is a differential diagnosis for many medical problems as the disease presents with nonspecific clinical signs that can include lethargy, weight gain, cold intolerance, and dermatologic manifestations such as alopecia. Alopecia is a frequently reported problem in captive nonhuman primates (NHP), and hypothyroidism is considered to be a differential diagnosis. However, thyroid function test results in NHP using total T4 (TT4) and free T4 (FT4) assays are difficult to interpret without accurate reference intervals (RI) for comparison. As a consequence, hypothyroidism may be underdiagnosed in these species. The objective of this study was to establish RI for TT4 and FT4 in healthy populations of cynomolgus macaques (

Indexed as

Hematologic TestsThyroid Function TestsAnimalsMacaca fascicularisMacaca mulattaReference Values

Identifiers

PMID34210383
PMCPMC8483642
OpenAlexW3174762849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.