ArticleCritical care (London, England)2021
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.
Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Very Old Intensive Care Patient: A Multinational Prospective Observation Study
Development and Validation of a Prognostic Score in the Very Old ICU Patients (≥80 Years)
Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- [The geriatric syndrome frailty in the context of readmission to the intensive care unit : Study protocol of a mixed-methods study].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Predicting weaning failure in critically ill older patients: secondary analysis of a national multicenter prospective cohort in Türkiye.BMC geriatrics · 2026Observational
- Mild to moderate frailty among older adults does not affect long-term quality of life or functional outcomes after colon cancer surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Observational
- Clinical frailty score for hospital outcome for patients aged ≥ 75 following emergency department resuscitation room admission: a retrospective monocenter study.Internal and emergency medicine · 2026Article
- Guidelines for the Initial Assessment of Respiratory Distress in the Emergency Department.Annals of intensive care · 2026Article
- Clinical Characteristics and Outcomes in Patients Aged ≥80 Years Treated in the Intensive Care Units of a Large Multispecialty Metropolitan Hospital in Poland.Journal of clinical medicine · 2025Article
- Analysis of frailty change trajectories and its risk factors in patients with gastrointestinal tumor surgery: a prospective observational longitudinal study.World journal of surgical oncology · 2025Observational
- Prognosis of Nonagenarian ICU Patients A Bayesian analysis of prospective European studies.Annals of intensive care · 2025Article
- Frailty and long-term survival of non-cancer patients admitted to intensive care after surgery: a retrospective multicentre cohort study.British journal of anaesthesia · 2025Article
- The pictorial fit-frail scale: a novel tool for frailty assessment in critically ill older adults.BMC geriatrics · 2025Article
- Decision-making in interhospital transfer of traumatic brain injury patients: exploring the perspectives of surgeons at general hospitals and neurosurgeons at neurotrauma centres.BMC health services research · 2025Article
- Clinical Frailty Scale score is a predictor of short-, mid- and long-term mortality in critically ill older adults (≥ 70 years) admitted to the emergency department: an observational study.BMC geriatrics · 2024Observational
- Advance care planning in patients with respiratory failure.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Agreement and predictive value of the clinical frailty scale in hospitalized older patients.European geriatric medicine · 2024Article
- Glycated Albumin and Adverse Clinical Outcomes in Patients With CKD: A Prospective Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Frailty is crucial in FORECASTing outcomes in critical care.Intensive care medicine · 2024Article
- Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis.Critical care (London, England) · 2024Article
- Limited incremental predictive value of the frailty index and other vulnerability measures from routine care data for mortality risk prediction in older patients with COVID-19 in primary care.BMC primary care · 2024Article
- Predictors of outcomes of patients ≥ 80 years old admitted to intensive care units in Poland - a post-hoc analysis of the VIP2 prospective observational study.Anaesthesiology intensive therapy · 2024Observational
Corrections and comments
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Authors and funding
32 authors at 20 institutions in 17 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context.
methodsWe analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient's age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score.
resultsThe median age in the sample of 7487 consecutive patients was 84 years (IQR 81-87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01).
conclusionKnowledge about a patient's frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.