Evidence map›Paper›PMID 34210328›Full record

ArticleBMC veterinary research2021

Effect of in-vitro heat stress challenge on the function of blood mononuclear cells from dairy cattle ranked as high, average and low immune responders.

Shannon L Cartwright, Marnie McKechnie, Julie Schmied, Alexandra M Livernois, Bonnie A Mallard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Physiological impact of amino acids during heat stress in ruminants.Animal frontiers : the review magazine of animal agriculture · 2023
    Article
  9. Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023
    Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shannon L CartwrightDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Rd, Guelph, ON, N1G 2W1, Canada. cartwris@uoguelph.ca.ORCID http://orcid.org/0000-0002-0814-8275
Marnie McKechnieDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Rd, Guelph, ON, N1G 2W1, Canada.
Julie SchmiedDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Rd, Guelph, ON, N1G 2W1, Canada.
Alexandra M LivernoisDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Rd, Guelph, ON, N1G 2W1, Canada.
Bonnie A MallardDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Rd, Guelph, ON, N1G 2W1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe warming climate is causing livestock to experience heat stress at an increasing frequency. Holstein cows are particularly susceptible to heat stress because of their high metabolic rate. Heat stress negatively affects immune function, particularly with respect to the cell-mediated immune response, which leads to increased susceptibility to disease. Cattle identified as having enhanced immune response have lower incidence of disease. Therefore, the objective of this study was to evaluate the impact of in vitro heat challenge on blood mononuclear cells from dairy cattle, that had previously been ranked for immune response, in terms of heat shock protein 70 concentration, nitric oxide production, and cell proliferation.

resultsBlood mononuclear cells from dairy cattle classified as high immune responders, based on their estimated breeding values for antibody and cell-mediated responses, produced a significantly greater concentration of heat shock protein 70 under most heat stress treatments compared to average and low responders, and greater cell-proliferation across all treatments. Similarly, a trend was observed where high responders displayed greater nitric oxide production compared to average and low responders across heat treatments.

conclusionOverall, these results suggest that blood mononuclear cells from high immune responder dairy cows are more thermotolerant compared to average and low immune responders.

Indexed as

ImmunityAnimalsCattleDairyingFemaleHeat-Shock ResponseHSP70 Heat-Shock ProteinsLeukocytes, MononuclearNitric OxideHSP70 Heat-Shock ProteinsNitric OxideCell proliferationDairy cattleHeat shock protein 70 concentrationHeat stressImmune responseNitric oxide production

Identifiers

PMID34210328
PMCPMC8252269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.