ArticleBMC infectious diseases2021
Antibiotic susceptibility of human-associated Staphylococcus aureus and its relation to agr typing, virulence genes, and biofilm formation.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 41 citations in OpenAlex.
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- Reciprocal adaptation is critical in enhancing S. aureus and P. aeruginosa biofilm biomass.Archives of microbiology · 2026Article
- Phenotypic and genomic features of virulent mecA-carrying Staphylococcus hyicus isolated from a pig farm with fatal exudative epidermitis.BMC veterinary research · 2026Article
- Relationship between agr types, toxin genes, and antibiotic resistance in clinical Staphylococcus aureus isolates.Molecular biology reports · 2026Article
- Hijacking the signal: a critical evaluation of quorum sensing inhibitors as a next-generation approach against Staphylococcus aureus.Cell communication and signaling : CCS · 2026Review
- The dual-species biofilm formed by Staphylococcus aureus and Pseudomonas fluorescens exhibited enhanced resistance to disinfectants.NPJ science of food · 2025Article
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- Coexistence of the blaZ gene and selected virulence determinants in multidrug-resistant Staphylococcus aureus: insights from three Nigerian tertiary hospitals.BMC infectious diseases · 2024Article
- Investigation of antimicrobial resistance and antimicrobial resistance genes inVeterinary world · 2024Article
- Biofilm Formation by Hospital-Acquired Resistant Bacteria Isolated from Respiratory Samples.Journal of epidemiology and global health · 2024Article
- Antibiotic Therapy and Prophylaxis for Snake-Bitten Patients.The American journal of tropical medicine and hygiene · 2024Article
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- Exploration ofFrontiers in cellular and infection microbiology · 2024Article
- Myrtenol's Effectiveness against Hospital-Acquired Methicillin-ResistantInternational journal of microbiology · 2024Article
- Lugdunin production and activity inMicrobiology spectrum · 2023Article
- Comparative De Novo and Pan-Genome Analysis of MDR Nosocomial Bacteria Isolated from Hospitals in Jeddah, Saudi Arabia.Microorganisms · 2023Article
- The Prevalence of the Virulence Genes ofAntibiotics (Basel, Switzerland) · 2023Article
- Chemical and biomolecular insights into theIsrael journal of chemistry · 2023Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveCarriage of virulence factors confers some evolutionary benefit to bacteria, which favors the resistant strains. We aimed to analyze whether antibiotic susceptibility of Staphylococcus aureus strains is affected by agr typing, biofilm formation ability, and virulence profiles.
methodsA total of 123 S. aureus clinical isolates were subjected to antimicrobial susceptibility testing by disk diffusion method, biofilm formation by microtiter plate method, as well as polymerase chain reaction screening to identify virulence genes and the accessory gene regulator (agr) types I-IV. A P value < 0.05 was considered significant.
resultsThe most prevalent virulence gene was staphyloxanthin crtN, followed by hemolysin genes, capsular cap8H, toxic shock toxin tst, and enterotoxin sea, respectively. Resistant isolates were more commonly found in the agr-negative group than in the agr-positive group. Isolates of agr type III were more virulent than agr I isolates. Strong biofilm producers showed more antibiotic susceptibility and carried more virulence genes than non-strong biofilm producers. Associations were found between the presence of virulence genes and susceptibility to antibiotics. Carriage of the virulence genes and agr was higher in the inpatients; while, resistance and strong biofilms were more prevalent in the outpatients.
conclusionThese findings indicated the presence of several virulence factors, biofilm production capacity, agr types and resistance to antibiotics in clinical S. aureus isolates. Considering the importance of S. aureus for human medicine, an understanding of virulence and resistance relationships would help to reduce the impact of S. aureus infections.
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