Evidence map›Paper›PMID 34210221›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen

Krzysztof M Zak, Mark J Bostock, Irena Waligorska, Ida B Thøgersen, Jan J Enghild, Grzegorz M Popowicz, Przemyslaw Grudnik, Jan Potempa, Miroslaw Ksiazek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Leptolysin, aFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Krzysztof M ZakHelmholtz Zentrum München, Institute of Structural Biology, Neuherberg, Germany.ORCID https://orcid.org/0000-0001-5844-6599
Mark J BostockHelmholtz Zentrum München, Institute of Structural Biology, Neuherberg, Germany.ORCID https://orcid.org/0000-0001-6717-5786
Irena WaligorskaDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Ida B ThøgersenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Jan J EnghildDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Grzegorz M PopowiczHelmholtz Zentrum München, Institute of Structural Biology, Neuherberg, Germany.
Przemyslaw GrudnikMalopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.
Jan PotempaDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID https://orcid.org/0000-0002-3600-7461
Miroslaw KsiazekDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID https://orcid.org/0000-0002-6295-9247
Jagiellonian University · PLAarhus University · DKCenter for Integrated Protein Science Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mirolysin is a secretory protease of

Indexed as

Bacterial ProteinsDrug DiscoveryElectrophoresis, Polyacrylamide GelEnzyme StabilityHumansMagnetic Resonance SpectroscopyMolecular Docking SimulationMolecular StructurePeptide HydrolasesPeriodontitisProtease InhibitorsTannerella forsythiaTemperatureBacterial ProteinsPeptide HydrolasesProtease InhibitorsNMR-based fragment screeningPeriodontitisprotease inhibitorsproteolysisTannerella forsythia

Identifiers

PMID34210221
PMCPMC8259862
OpenAlexW3176531647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.