Evidence map›Paper›PMID 34210212›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases.

Mohamed Mokhtar, Khadijah S Alghamdi, Nesreen S Ahmed, Dina Bakhotmah, Tamer S Saleh

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mohamed MokhtarChemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0002-0594-7207
Khadijah S AlghamdiChemistry Department, Faculty of Science, Albaha University, Albaha, Saudi Arabia.
Nesreen S AhmedDepartment of Therapeutic Chemistry, National Research Centre, Cairo,Egypt.ORCID https://orcid.org/0000-0001-9136-9986
Dina BakhotmahChemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0001-6651-7932
Tamer S SalehDepartment of Chemistry, University of Jeddah, College of Science, Jeddah, Saudi Arabia.
King Abdulaziz University · SAAl Baha University · SANational Research Centre · EGUniversity of Jeddah · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new set of 4,6,7,8-tetrahydroquinolin-5(1H)-ones were designed as cytotoxic agents against breast cancer cell line (MCF-7) and synthesised under ultrasonic irradiation using chitosan decorated copper nanoparticles (CS/CuNPs) catalyst. The new compounds

Indexed as

Green Chemistry TechnologyAntineoplastic AgentsBreast NeoplasmsCell LineDrug DesignDrug Screening Assays, AntitumorFemaleHumansMCF-7 CellsMolecular Docking SimulationProtein Kinase InhibitorsQuinolonesReceptor Protein-Tyrosine KinasesSpectrum AnalysisAntineoplastic AgentsProtein Kinase InhibitorsQuinolonesReceptor Protein-Tyrosine Kinases4,6,7,8-Tetrahydroquinolin-5(1H)-oneapoptosisbreast cancerHER-2 inhibitorsmolecular docking study

Identifiers

PMID34210212
PMCPMC8259865
OpenAlexW3175057664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.