Evidence map›Paper›PMID 34210154›Full record

ArticleThyroid : official journal of the American Thyroid Association2021

Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study.

Christina Ellervik, Samia Mora, Aleksander Kuś, Bjørn Åsvold, Eirini Marouli, Panos Deloukas, Rosalie B T M Sterenborg, Alexander Teumer, Stephen Burgess, Maria Sabater-Lleal and 8 more

Open access · goldAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  9. Amiodarone Therapy: Updated Practical Insights.Journal of clinical medicine · 2024
    Review
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  18. The Thyroid Hormone Axis and Female Reproduction.International journal of molecular sciences · 2023
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 16 institutions in 11 countries.

Christina EllervikDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-3088-4375
Samia MoraCenter for Lipid Metabolomics, Division of Preventive Medicine; Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Aleksander KuśDepartment of Internal Medicine, Academic Center for Thyroid Diseases; Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5422-6900
Bjørn ÅsvoldK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID 0000-0003-3837-2101
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Rosalie B T M SterenborgDepartment of Internal Medicine, Academic Center for Thyroid Diseases; Erasmus Medical Center, Rotterdam, The Netherlands.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Stephen BurgessMRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.
Maria Sabater-LlealGenomics of Complex Diseases Group, Research Institute Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain.
Jennifer HuffmanScientific Director for Genomics Research, Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.
Andrew D JohnsonNational Heart, Lung and Blood Institute's The Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
David-Alexandre TrégouetINSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Nicolas L SmithDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Marco MediciDepartment of Internal Medicine, Academic Center for Thyroid Diseases; Erasmus Medical Center, Rotterdam, The Netherlands.
Paul S DeVriesDepartment of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Daniel I ChasmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Alisa D KjaergaardSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3899-1324
Queen Mary University of London · GBRadboud University Nijmegen · NLBrigham and Women's Hospital · USBroad Institute · USFramingham Heart Study · USHospital de Sant Pau · ESMedical University of Warsaw · PLNorwegian University of Science and Technology · NOSteno Diabetes Centers · DKThe University of Texas Health Science Center at Houston · USUniversitätsmedizin Greifswald · DEUniversité de Bordeaux · FRUniversity of Cambridge · GBUniversity of Copenhagen · DKUniversity of Washington · USVA Boston Healthcare System · US

Funding

Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
Analysis of Whole Genome Sequence and Hemostasis PhenotypesR01HL139553 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI PAUL STEFAN DE VRIES, Alanna C Morrison · 2018 to 2026
$5.0M
Using genomics and functional biology to understand fibrinogen and its effect on thrombotic and atherosclerotic outcomesR01HL141291 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Alanna C Morrison, Alisa S. Wolberg · 2019 to 2026
$4.6M
Women's Health Study: Infrastructure support for continued cohort follow-upU01CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2019 to 2023
$4.0M
Population genomic variation, functional biology, and the risk of venous thrombosisR01HL134894 · NHLBI · UNIVERSITY OF WASHINGTON · PI LOWENSTEIN, CHARLES J, SMITH, NICHOLAS L · 2017 to 2020
$2.9M
Patient Centered Approaches to Preventing ASCVD EventsK24HL136852 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAMIA MORA · 2018 to 2026
$1.1M
British Heart Foundation CH/12/2/29428British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MC_UU_00002/7NCI NIH HHS U01 CA182913NHLBI NIH HHS K24 HL136852NHLBI NIH HHS R01 HL134894NHLBI NIH HHS R01 HL139553NHLBI NIH HHS R01 HL141291Wellcome Trust 204623/Z/16/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Polymorphism, Single NucleotideAutoantibodiesBiomarkersBlood CoagulationBlood Coagulation FactorsBlood Coagulation TestsCase-Control StudiesFibrinolysisGenetic Predisposition to DiseaseGenome-Wide Association StudyHemostasisHumansHyperthyroidismHypothyroidismMendelian Randomization AnalysisPhenotypeanti-thyroid autoantibodiesAutoantibodiesBiomarkersBlood Coagulation FactorsThyrotropinThyroxinevon Willebrand Factorcoagulationfibrinolysishemostasishyperthyroidismhypothyroidismthyroid hormonethyroid peroxidase antibodythyrotropin

Identifiers

PMID34210154
PMCPMC8558080
OpenAlexW3173202158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.