Evidence map›Paper›PMID 34210040›Full record

ArticleMicroorganisms2021

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series.

Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille, Sarah Hendrickx, Lindsay B Tulloch, Richard J Wall, Susan Wyllie, Eric Chatelain, Charles E Mowbray, Stéphanie Braillard and 3 more

Abstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Population pharmacokinetics of DNDI-6148 in healthy adults.PLoS neglected tropical diseases · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Current leishmaniasis drug discovery.RSC medicinal chemistry · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Magali Van den KerkhofLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.
Philippe LeprohonCentre de Recherche en Infectiologie du Centre de Recherche du Centre Hospitalier Universitaire de Québec, Université Laval, Québec City, QC G1V 0A6, Canada.
Dorien MabilleLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0003-3530-0567
Sarah HendrickxLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.
Lindsay B TullochThe Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Richard J WallThe Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Susan WyllieThe Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Eric ChatelainDrugs for Neglected Diseases initiative (DNDi), 1202 Geneva, Switzerland.
Charles E MowbrayDrugs for Neglected Diseases initiative (DNDi), 1202 Geneva, Switzerland.
Stéphanie BraillardDrugs for Neglected Diseases initiative (DNDi), 1202 Geneva, Switzerland.
Marc OuelletteCentre de Recherche en Infectiologie du Centre de Recherche du Centre Hospitalier Universitaire de Québec, Université Laval, Québec City, QC G1V 0A6, Canada.
Louis MaesLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0002-2324-9509
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0002-4870-3202

Funding

Fonds Wetenschappelijk Onderzoek 12I0317NFonds Wetenschappelijk Onderzoek G051812NUniversiteit Antwerpen TT-ZAPBOF 33049Wellcome Trust 203134/Z/16/Z
6 · The paper itself

Abstract

Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. To overcome this, the Drugs for Neglected Diseases

Indexed as

ABC transportersLeishmaniaoxaborolesresistance

Identifiers

PMID34210040
PMCPMC8305145

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.