Evidence map›Paper›PMID 34209940›Full record

ArticlePharmaceutics2021

API Content and Blend Uniformity Using Quantum Cascade Laser Spectroscopy Coupled with Multivariate Analysis.

Vladimir Villanueva-López, Leonardo C Pacheco-Londoño, Reynaldo Villarreal-González, John R Castro-Suarez, Andrés Román-Ospino, William Ortiz-Rivera, Nataly J Galán-Freyle, Samuel P Hernandez-Rivera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vladimir Villanueva-LópezALERT DHS Center of Excellence for Explosives Research, Department of Chemistry, University of Puerto Rico, Mayagüez, PR 00681, USA.
Leonardo C Pacheco-LondoñoALERT DHS Center of Excellence for Explosives Research, Department of Chemistry, University of Puerto Rico, Mayagüez, PR 00681, USA.ORCID 0000-0002-5770-3706
Reynaldo Villarreal-GonzálezAudacIA Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
John R Castro-SuarezALERT DHS Center of Excellence for Explosives Research, Department of Chemistry, University of Puerto Rico, Mayagüez, PR 00681, USA.
Andrés Román-OspinoEngineering Research Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
William Ortiz-RiveraALERT DHS Center of Excellence for Explosives Research, Department of Chemistry, University of Puerto Rico, Mayagüez, PR 00681, USA.
Nataly J Galán-FreylePharmaceutical Chemistry Department, School of Basic and Biomedical Sciences, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Samuel P Hernandez-RiveraALERT DHS Center of Excellence for Explosives Research, Department of Chemistry, University of Puerto Rico, Mayagüez, PR 00681, USA.ORCID 0000-0003-2536-6693

Funding

Defense Threat Reduction Agency DODRIF11-DTRA020-P-0017U.S. Department of Defense W911NF-11-1-0152U.S. Department of Homeland Security 2013-ST-061-ED0001
6 · The paper itself

Abstract

The process analytical technology (PAT) initiative proposed by the US Food and Drug Administration (FDA) suggests innovative methods to better understand pharmaceutical processes. The development of analytical methods that quantify active pharmaceutical ingredients (APIs) in powders and tablets is fundamental to monitoring and controlling a drug product's quality. Analytical methods based on vibrational spectroscopy do not require sample preparation and can be implemented during in-line manufacturing to maintain quality at each stage of operations. In this study, a mid-infrared (MIR) quantum cascade laser (QCL) spectroscopy-based protocol was performed to quantify ibuprofen in formulations of powder blends and tablets. Fourteen blends were prepared with varying concentrations from 0.0% to 21.0% (

Indexed as

blend uniformitycontent uniformityinfrared spectroscopyPATquantum cascade laser

Identifiers

PMID34209940
PMCPMC8309115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.