ArticleMaterials (Basel, Switzerland)2021
Cranberry Juice Extract Rapidly Protects Demineralized Dentin against Digestion and Inhibits Its Gelatinolytic Activity.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Polyphenol-functionalized silver nanoparticles promote differential remineralization and reinforcement of demineralized dentin.Journal of applied oral science : revista FOB · 2026Article
- Exploring the Benefits of Cranberries in Dentistry: A Comprehensive Review.Biomedicines · 2025Review
- Effects of Grape Seed Extract-Modified Etchants on Collagenolytic Activity, Interface Formation, and Bonding Longevity of Adhesive-Dentin Interfaces.Materials (Basel, Switzerland) · 2025Article
- Effects of crosslinker-modified etchants on durability of resin-dentin bonds in sound and caries-affected dentin.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- The Influence of Various Crosslinking Conditions of EDC/NHS on the Properties of Fish Collagen Film.Marine drugs · 2024Article
- The action of microbial collagenases in dentinal matrix degradation in root caries and potential strategies for its management: a comprehensive state-of-the-art review.Journal of applied oral science : revista FOB · 2024Review
- Effect of Different Crosslinkers on Denatured Dentin Collagen's Biostability, MMP Inhibition and Mechanical Properties.Polymers · 2023Article
- Evaluation of the remineralizing capacity of silver diamine fluoride on demineralized dentin under pH-cycling conditions.Journal of applied oral science : revista FOB · 2023Article
- Distinct effects of polyphenols and solvents on dentin collagen crosslinking interactions and biostability.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Theaflavins as a novel cross-linker quickly stabilize demineralized dentin collagen against degradation.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Improving the longevity of composite restorations has proven to be difficult when they are bonded to dentin. Dentin demineralization leaves collagen fibrils susceptible to enzymatic digestion, which causes breakdown of the resin-dentin interface. Therefore, measures for counteracting the enzymatic environment by enhancing dentin collagen's resistance to degradation have the potential to improve the durability of dental composite restorations. This study aimed to evaluate the effects of polyphenol-rich extracts and a chemical cross-linker on the cross-linking interaction, resistance to digestion, and endogenous matrix metalloproteinase (MMP) activities of dentin collagen under clinically relevant conditions. Ten-µm-thick films were cut from dentin slabs of non-carious extracted human third molars. Following demineralization, polyphenol-rich extracts-including grape seed (GSE), green tea (GTE), and cranberry juice (CJE)-or chemical cross-linker carbodiimide with n-hydroxysuccinimide (EDC/NHS) were applied to the demineralized dentin surfaces for 30 s. The collagen cross-linking, bio-stabilization, and gelatinolytic activities of MMPs 2 and 9 were studied by using Fourier-transform infrared spectroscopy, weight loss, hydroxyproline release, scanning/transmission electron microscopy, and in situ zymography. All treatments significantly increased resistance to collagenase degradation and reduced the gelatinolytic MMP activity of dentin collagen compared to the untreated control. The CJE- and GSE-treated groups were more resistant to digestion than the GTE- or EDC/NHS-treated ones (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.