SynthesisInternational journal of molecular sciences2021
Saliva Proteomics as Fluid Signature of Inflammatory and Immune-Mediated Skin Diseases.
Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Potential of Salivary Biomarkers in Autism Research: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026Review
- Evaluation of Salivary GAPDH as a Predictor Biomarker for Periodontitis.International journal of molecular sciences · 2025Article
- Biomarkers in Atopic Dermatitis in Children: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Saliva as a Diagnostic Tool for Systemic Diseases-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Medwakh smoking induces alterations in salivary proteins and cytokine expression: a clinical exploratory proteomics investigation.Clinical proteomics · 2025Article
- Challenges Psoriasis and Its Impact on Quality of Life: Challenges in Treatment and Management.Psoriasis (Auckland, N.Z.) · 2025Review
- The Impact of Nonsurgical Periodontal Therapy on the Salivary Proteome: A Pilot Study.International journal of dentistry · 2025Article
- Review
- Advances in Research on Pig Salivary Analytes: A Window to Reveal Pig Health and Physiological Status.Animals : an open access journal from MDPI · 2024Review
- Alterations of oral microbiome and metabolic signatures and their interaction in oral lichen planus.Journal of oral microbiology · 2024Article
- Ectopic pregnancy: search for biomarker in salivary proteome.Scientific reports · 2023Article
- Qualitative and Quantitative Mass Spectrometry in Salivary Metabolomics and Proteomics.Metabolites · 2023Review
- Proteomic Identification of Saliva Proteins as Noninvasive Diagnostic Biomarkers.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Proteomic characteristics of saliva in patients with different subgroups of IgG4-RD.Frontiers in immunology · 2022Article
- Psoriasis as an Immune-Mediated and Inflammatory Systemic Disease: From Pathophysiology to Novel Therapeutic Approaches.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saliva is easy to access, non-invasive and a useful source of information useful for the diagnosis of serval inflammatory and immune-mediated diseases. Following the advent of genomic technologies and -omic research, studies based on saliva testing have rapidly increased and human salivary proteome has been partially characterized. As a proteomic protocol to analyze the whole saliva proteome is not currently available, the most common aim of the proteomic analysis is to discriminate between physiological and pathological conditions. The salivary proteome has been initially investigated in several diseases: oral squamous cell carcinoma and oral leukoplakia, chronic graft-versus-host disease, and Sjögren's syndrome. Otherwise, salivary proteomics studies in the dermatological field are still in the initial phase, thus the aim of this review is to collect the best research evidence on the role of saliva proteomics analysis in immune-mediated skin diseases to understand the direction of research in this field. The results of PRISMA analysis reported herein suggest that human saliva analysis could provide significant data for the diagnosis and prognosis of several immune-mediated and inflammatory skin diseases in the next future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.