ArticleFoods (Basel, Switzerland)2021
Neuroprotective Effect of Terpenoids Recovered from Olive Oil By-Products.
Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A comprehensive review ofRSC advances · 2026Review
- Eco-Friendly Extraction of Olive Leaf Phenolics and Terpenes: A Comparative Performance Analysis Against Conventional Methods.Foods (Basel, Switzerland) · 2025Article
- Exploring the Impact of Olive-Derived Bioactive Components on Gut Microbiota: Implications for Digestive Health.Foods (Basel, Switzerland) · 2025Review
- Review
- Global Status, Recent Trends, and Knowledge Mapping of Olive Bioactivity Research Through Bibliometric Analysis (2000-2024).Foods (Basel, Switzerland) · 2025Review
- Effects of Olive Pomace and Spice Extracts on Performance and Antioxidant Function in Broiler Chickens.Animals : an open access journal from MDPI · 2025Article
- Research progress on phytochemistry and pharmacology ofFrontiers in pharmacology · 2025Review
- Eplingiella fruticosa leaf essential oil complexed with β-cyclodextrin exerts a neuroprotective effect in an Alzheimer's disease animal model induced by Streptozotocin.Metabolic brain disease · 2024Article
- The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer's Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial.Neurology international · 2024Article
- Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications-A Comprehensive Overview.Molecules (Basel, Switzerland) · 2024Review
- Characterization of Phenolic Compounds in Extra Virgin Olive Oil from Granada (Spain) and Evaluation of Its Neuroprotective Action.International journal of molecular sciences · 2024Article
- Article
- Introducing of high rich lysine, arginine, and unsaturated fatty acids microalga as a food supplement.World journal of microbiology & biotechnology · 2023Article
- Cannabis sativa-based oils against aluminum-induced neurotoxicity.Scientific reports · 2023Article
- Review
- Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer's Disease.International journal of molecular sciences · 2023Review
- In Vitro Study of the Blood-Brain Barrier Transport of Natural Compounds Recovered from Agrifood By-Products and Microalgae.International journal of molecular sciences · 2022Article
- Phytochemical Compounds and Nanoparticles as Phytochemical Delivery Systems for Alzheimer's Disease Management.Molecules (Basel, Switzerland) · 2022Review
- The Protective and Therapeutic Anti-Alzheimer Potential ofMetabolites · 2022Article
- Study of the potential neuroprotective effect of Dunaliella salina extract in SH-SY5Y cell model.Analytical and bioanalytical chemistry · 2022Article
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Authors and funding
8 authors.
Funding
Abstract
The neuroprotective potential of 32 natural extracts obtained from olive oil by-products was investigated. The online coupling of supercritical fluid extraction (SFE) and dynamic adsorption/desorption allowed the selective enrichment of olive leaves extracts in different terpenoids' families. Seven commercial adsorbents based on silica gel, zeolite, aluminum oxide, and sea sand were used with SFE at three different extraction times to evaluate their selectivity towards different terpene families. Collected fractions were analyzed by gas chromatography coupled to quadrupole-time-of-flight mass spectrometry (GC-QTOF-MS) to quantify the recoveries of monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), and triterpenes (C30). A systematic analysis of the neuroprotective activity of the natural extracts was then carried out. Thus, a set of in vitro bioactivity assays including enzymatic (acetylcholinesterase (AChE), butyrylcholinesterase (BChE)), and anti-inflammatory (lipoxidase (LOX)), as well as antioxidant (ABTS), and reactive oxygen and nitrogen species (ROS and RNS, respectively) activity tests were applied to screen for the neuroprotective potential of these extracts. Statistical analysis showed that olive leaves adsorbates from SS exhibited the highest biological activity potential in terms of neuroprotective effect. Blood-brain barrier permeation and cytotoxicity in HK-2 cells and human THP-1 monocytes were studied for the selected olive leaves fraction corroborating its potential.
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