Evidence map›Paper›PMID 34209843›Full record

ArticleMolecules (Basel, Switzerland)2021

Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2

Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A MacDonald and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  7. Inflammasome Inhibitors.Molecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Simone GastaldiDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.ORCID 0000-0003-0487-3266
Valentina BoscaroDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.ORCID 0000-0002-3344-8624
Eleonora GianquintoDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Christina F SandallDepartment of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.ORCID 0000-0002-8195-4054
Marta GiorgisDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.ORCID 0000-0002-3282-1220
Elisabetta MariniDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Federica BluaDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Margherita GallicchioDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Francesca SpyrakisDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.ORCID 0000-0002-4016-227X
Justin A MacDonaldDepartment of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.ORCID 0000-0002-9238-8473
Massimo BertinariaDepartment of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.ORCID 0000-0002-2533-5830
University of Turin · ITUniversity of Calgary · CA

Funding

Compagnia di San Paolo Bando San Paolo ex-post BERM_S1618_19_01Fondazione CRT RF2018.0613Natural Sciences and Engineering Research Council of Canada RGPIN/04379-2019Università degli Studi di Torino MARE_RILO_19_02; SPYF_RILO_19_02
6 · The paper itself

Abstract

In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2

Indexed as

ImidazolesHumansInflammasomesInterleukin-1betaMacrophagesNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisTHP-1 CellsIL1B protein, humanImidazolesInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanATP hydrolysisinterleukin-1βMD simulationsNLRP3 inhibitorspyroptosis

Identifiers

PMID34209843
PMCPMC8271538
OpenAlexW3177377376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.