Evidence map›Paper›PMID 34209801›Full record

ReviewJournal of clinical medicine2021

ISIDOG Consensus Guidelines on COVID-19 Vaccination for Women before, during and after Pregnancy.

Gilbert G G Donders, Svitrigaile Grinceviciene, Kai Haldre, Risa Lonnee-Hoffmann, Francesca Donders, Aristotelis Tsiakalos, Albert Adriaanse, José Martinez de Oliveira, Kevin Ault, Werner Mendling and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Worldwide beliefs among pregnant women on SARS-CoV-2 vaccine: a systematic review.European journal of obstetrics, gynecology, and reproductive biology · 2022
    Pooled it
  3. Review
  4. Knowledge and attitudes of pregnant women about COVID-19 vaccination.Revista latino-americana de enfermagem · 2025
    Article
  5. Review
  6. Awareness and Safety of COVID-19 Vaccination in Pregnancy.Journal of obstetrics and gynaecology of India · 2024
    Article
  7. Article
  8. Covid-19 vaccination in pregnancy.BMJ (Clinical research ed.) · 2022
    Review
  9. Dengue and COVID-19: two sides of the same coin.Journal of biomedical science · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. How to think about severe acute respiratory syndrome coronavirus 2 vaccination for pregnant and lactating women in China.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 8 countries.

Gilbert G G DondersFemicare VZW Clinical Research for Women, 3300 Tienen, Belgium.ORCID 0000-0001-9890-6254
Svitrigaile GrincevicieneDepartment Biothemodynamics and Drug Design, Institute of Biotechnology and Life Sciences Center, Vilnius University, 01513 Vilnius, Lithuania.
Kai HaldreEast Tallin Central Hospital Women's Clinic, 10138 Tallin, Estonia.
Risa Lonnee-HoffmannDepartment Gynecology, Hospital St Olav, 7030 Trondheim, Norway.
Francesca DondersFemicare VZW Clinical Research for Women, 3300 Tienen, Belgium.ORCID 0000-0003-0376-0067
Aristotelis TsiakalosLETO-Obstetrician Gynecological & Surgical Center, Department Obstetrics and Gynecology, 11525 Athens, Greece.
Albert AdriaanseMedisch Centrum Alkmaar, Department Obstetrics and Gynecology, 1814 Alkmaar, The Netherlands.
José Martinez de OliveiraDepartment Obstetrics and Gynecology, Universidade da Beira Interior, 6201-001 Covilha, Portugal.
Kevin AultDepartment Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Werner MendlingGerman Center for Infections in Obstetrics and Gynceology, Department Obstetrics and Gynecology, 42283 Wupperthal, Germany.
On The Behalf Of The Covid-Isidog Guideline Group
Antwerp University Hospital · BEEast Tallinn Central Hospital · EELETO Maternity Hospital · GRMedisch Centrum Alkmaar · NLSt Olav's University Hospital · NOUniversity of Beira Interior · PTUniversity of Kansas Medical Center · USVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSars-CoV-2 infection poses particular problems in pregnancy, as the infection more frequently causes severe complications than in unaffected pregnant women or nonpregnant women with SARS-CoV-2 infection. Now that vaccination is available and rapidly being implemented worldwide, the question arises whether pregnant women should be vaccinated, and if so, whether they should receive priority.

methodsAvailable scientific data and available guidelines about vaccination against SARS-CoV-2 were collected by the Guideline Committee of the International Society of Infectious Diseases in Obstetrics and Gynecology (ISIDOG) and were analyzed, discussed and summarized as guidelines for healthcare workers caring for pregnant women. Concluding statements were graded according to the Oxford evidence-based medicine grading system.

resultsThere is evidence to consider pregnancy as a risk factor for serious complications of COVID-19 infection, even in the absence of additional risk factors, such as hypertension, diabetes and obesity which increase these risks even more in pregnancy. Currently available data slightly favor mRNA-based vaccines above vector-based vaccines during pregnancy and breastfeeding, until more safety data become available.

conclusionISIDOG advises policy makers and societies to prioritize pregnant women to receive vaccination against SARS-CoV-2 and favor the mRNA vaccines until further safety information becomes available.

Indexed as

COVID-19maternal complicationspandemicpregnancy complicationpreventionsafetySARS-CoV-2vaccine

Identifiers

PMID34209801
PMCPMC8268868
OpenAlexW3175148912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.