Evidence map›Paper›PMID 34209762›Full record

ArticleCells2021

Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer's Disease.

Dimitrios Vlachakis, Eleni Papakonstantinou, Ram Sagar, Flora Bacopoulou, Themis Exarchos, Panos Kourouthanassis, Vasileios Karyotis, Panayiotis Vlamos, Constantine Lyketsos, Dimitrios Avramopoulos and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  3. Review
  4. Review
  5. Epitranscriptomics of cardiovascular diseases (Review).International journal of molecular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Dimitrios VlachakisLaboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece.ORCID 0000-0003-1823-6102
Eleni PapakonstantinouLaboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece.
Ram SagarDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-4297-2639
Flora BacopoulouUniversity Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Themis ExarchosBioinformatics and Human Electrophysiology Laboratory, Ionian University, 49100 Corfu, Greece.
Panos KourouthanassisBioinformatics and Human Electrophysiology Laboratory, Ionian University, 49100 Corfu, Greece.
Vasileios KaryotisBioinformatics and Human Electrophysiology Laboratory, Ionian University, 49100 Corfu, Greece.ORCID 0000-0002-2841-9925
Panayiotis VlamosBioinformatics and Human Electrophysiology Laboratory, Ionian University, 49100 Corfu, Greece.ORCID 0000-0003-0053-7847
Constantine LyketsosThe Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Johns Hopkins Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD 21287, USA.ORCID 0000-0003-3827-4720
Dimitrios AvramopoulosDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Vasiliki MahairakiDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Ionian University · GRJohns Hopkins University · USAgricultural University of Athens · GRNational and Kapodistrian University of Athens · GR

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
NIA NIH HHS P30 AG066507The Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease at Johns Hopkins. gift account
6 · The paper itself

Abstract

The treatment of complex and multifactorial diseases constitutes a big challenge in day-to-day clinical practice. As many parameters influence clinical phenotypes, accurate diagnosis and prompt therapeutic management is often difficult. Significant research and investment focuses on state-of-the-art genomic and metagenomic analyses in the burgeoning field of Precision (or Personalized) Medicine with genome-wide-association-studies (GWAS) helping in this direction by linking patient genotypes at specific polymorphic sites (single-nucleotide polymorphisms,

Indexed as

Genetic Predisposition to DiseaseAlzheimer DiseaseBiomarkersHumansMultifactorial InheritanceRisk FactorsBiomarkersAlzheimer’s diseasebiomarkerspolygenic risk scores

Identifiers

PMID34209762
PMCPMC8305482
OpenAlexW3173787015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.