ReviewBrain sciences2021
Implications of Circadian Rhythm in Stroke Occurrence: Certainties and Possibilities.
Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Assessment of Socio-Demographic and Clinical Characteristics of Stroke Patients of a Tertiary Hospital in Bangladesh: A Cross-Sectional Study.Health science reports · 2026Article
- Difference of onset rhythm in acute ischemic stroke patients with different TOAST subtypes.PloS one · 2026Article
- The Influence of Circadian Onset Time on Admission Severity in Acute Ischemic Stroke: A Retrospective Cohort Study.Journal of central nervous system disease · 2026Article
- Circadian modulation of surgical timing and postoperative outcomes in subarachnoid hemorrhage: a retrospective cohort analysis.BMC neurology · 2025Article
- Sleep and Stroke-An Overlooked Bidirectional Influence: Why Should Sleep and Vascular Neurologists Work Closer?Journal of clinical medicine · 2025Article
- Determinant-based grouping of SNPs and its application for detecting disease-associated genomic loci.NAR genomics and bioinformatics · 2025Article
- Analyzing temporal imaging patterns in acute ischemic stroke via DICOM-timestamps.Scientific reports · 2025Article
- Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review.Frontiers in cardiovascular medicine · 2025Review
- Association between circadian syndrome and gallstones in US adult: a cross-sectional study of NHANES 2017-2020.BMC gastroenterology · 2024Article
- Characteristics of 24-h ambulatory blood pressure monitoring in elderly hypertensive males: An observational study of 85 year older patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Observational
- Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Deciphering Post-Stroke Sleep Disorders: Unveiling Neurological Mechanisms in the Realm of Brain Science.Brain sciences · 2024Review
- Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring.Journal of clinical hypertension (Greenwich, Conn.) · 2024Observational
- Time of the day and season distribution among stroke code subtypes: differences between ischemic stroke, intracranial hemorrhage, and stroke mimic.Frontiers in neurology · 2024Article
- The Cardiac Circadian Clock: Implications for Cardiovascular Disease and its Treatment.JACC. Basic to translational science · 2023Review
- A New Paradigm for Neuroprotection Clinical Trials for Acute Ischemic Stroke.Translational stroke research · 2023Article
- Cardiomyocyte-specific disruption of the circadian BMAL1-REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart.Communications biology · 2023Article
- rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression.Translational stroke research · 2023Article
- Daily rhythm of dynamic cerebral autoregulation in patients after stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Current role and future perspectives of electroacupuncture in circadian rhythm regulation.Heliyon · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke occurrence is not randomly distributed over time but has circadian rhythmicity with the highest frequency of onset in the morning hours. This specific temporal pattern is valid for all subtypes of cerebral infarction and intracerebral hemorrhage. It also correlates with the circadian variation of some exogenous factors such as orthostatic changes, physical activity, sleep-awake cycle, as well as with endogenous factors including dipping patterns of blood pressure, or morning prothrombotic and hypofibrinolytic states with underlying cyclic changes in the autonomous system and humoral activity. Since the internal clock is responsible for these circadian biological changes, its disruption may increase the risk of stroke occurrence and influence neuronal susceptibility to injury and neurorehabilitation. This review aims to summarize the literature data on the circadian variation of cerebrovascular events according to physiological, cellular, and molecular circadian changes, to survey the available information on the chronotherapy and chronoprophylaxis of stroke and its risk factors, as well as to discuss the less reviewed impact of the circadian rhythm in stroke onset on patient outcome and functional status after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.